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Exercise Is an Adjuvant to Contemporary Dystrophy Treatments

Kostek, Matthew, C.1; Gordon, Bradley2

Exercise and Sport Sciences Reviews: January 2018 - Volume 46 - Issue 1 - p 34–41
doi: 10.1249/JES.0000000000000131

Duchenne muscular dystrophy is a lethal genetic disease of muscle wasting for which there is no cure. In healthy muscle, structure and function improve dramatically with exercise. In patients with dystrophy, little is known about the effects of exercise. As contemporary therapies rapidly progress and patients become more active, there is a need to understand the effects of exercise.

Here we examine the novel hypothesis that low-intensity exercise training can be used as an adjuvant with contemporary treatments (e.g., corticosteroids and exon skipping) for muscular dystrophy.

1Duquesne University, Pittsburgh, PA; and 2Department Department of Nutrition Food and Exercise Science, Florida State University, Tallahassee, FL

Address for correspondence: Matthew C. Kostek, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282412-396-5546 (E-mail:

Accepted for publication: August 21, 2017.

Editor: Monica J. Hubal, Ph.D., FACSM.

© 2018 American College of Sports Medicine