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Circadian Rhythms, Skeletal Muscle Molecular Clocks, and Exercise

Schroder, Elizabeth A.1,2; Esser, Karyn A.1,2

Exercise and Sport Sciences Reviews: October 2013 - Volume 41 - Issue 4 - p 224–229
doi: 10.1097/JES.0b013e3182a58a70
Journal Club

Skeletal muscle comprises approximately 40% of total body mass and, as such, contributes to maintenance of human health. In this review, we discuss the current state of knowledge regarding the role of molecular clocks in skeletal muscle. In addition, we discuss a new function for exercise as a time-setting cue for muscle and other peripheral tissues.

This review discusses the relationship between the molecular clock, skeletal muscle, and exercise.

1Center for Muscle Biology and 2Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY

Address for correspondence: Karyn A. Esser, University of Kentucky, Department of Physiology, 800 Rose St., MS508, Lexington, KY 40536 (E-mail:

Associate Editor: LaDora V. Thompson, Ph.D.

Accepted for publication: July 9, 2013.

© 2013 American College of Sports Medicine