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Myofilament Protein Alterations Promote Physical Disability in Aging and Disease

Miller, Mark S.1; Toth, Michael J.1,2

Exercise and Sport Sciences Reviews: April 2013 - Volume 41 - Issue 2 - p 93–99
doi: 10.1097/JES.0b013e31828bbcd8
Journal Club

Skeletal muscle contractile function declines with age and age-associated diseases. Although muscle atrophy undoubtedly contributes to this decrease, recent findings suggest that reduced myofilament protein content and function also may participate. Based on these data, we propose that age- and disease-related alterations in myofilament proteins represent one molecular mechanism contributing to the development of physical disability.

Aging and disease alter myofilament proteins at the molecular level, which influences whole-muscle performance and leads to physical disability.

1Department of Molecular Physiology and Biophysics and 2Department of Medicine, University of Vermont, College of Medicine, Burlington, VT

Address for correspondence: Michael J. Toth, Ph.D., Health Science Research Facility 126B, 149 Beaumont Avenue, University of Vermont, Burlington, VT 05405 (E-mail:

Accepted for publication: November 27, 2012.

Associate Editor: Gordon L. Warren, Ph.D., FACSM

©2013 The American College of Sports Medicine