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Physical Exercise and Mitochondrial Function in Human Skeletal Muscle

Tonkonogi, Michail1 2; Sahlin, Kent1 2

Exercise and Sport Sciences Reviews: July 2002 - Volume 30 - Issue 3 - p 129-137

TONKONOGI, M., and K. SAHLIN. Physical exercise and mitochondrial function in human skeletal muscle. Exerc. Sport Sci. Rev., Vol. 30, No. 3, pp. 129–137, 2002. Muscle adaptation to endurance training involves qualitative changes in intrinsic properties of mitochondria. After training, the ADP sensitivity of mitochondrion is decreased whereas the effect of creatine on respiration is increased. This results in an improved control of aerobic energy production. Acute exercise does not adversely affect mitochondrial function.

1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Stockholm University College of Sport Science, Sweden

Address for correspondence: Michail Tonkonogi, Department of Physiology and Pharmacology, Karolinska Institutet, Box 5626, 114 86 Stockholm, Sweden (E-mail:

Accepted for publication: March 19, 2002.

©2002 The American College of Sports Medicine