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Electron Paramagnetic Resonance: A High-Resolution Tool for Muscle Physiology

Thompson, LaDora V.1; Lowe, Dawn A.2; Ferrington, Deborah A.3; Thomas, David D.2

Exercise and Sport Sciences Reviews: January 2001 - Volume 29 - Issue 1 - p 3-6

THOMPSON, L.V., D.A. LOWE, D.A. FERRINGTON, and D.D. THOMAS, Electron paramagnetic resonance: a high-resolution tool for muscle physiology. Exerc. Sport Sci. Rev., Vol. 29, No. 1, pp 3-6, 2001. Skeletal muscle function can be altered by changes in protein structure and motion. Electron paramagnetic resonance (EPR) paired with site-directed spin labeling has been used to study the relationships between (a) muscle force and myosin structure and (b) muscle relaxation and Ca-ATPase motion and structure.

Departments of 1Physical Medicine and Rehabilitation, 2Biochemistry, Molecular Biology and Biophysics, and 3Ophthalmology, University of Minnesota, Minneapolis, Minnesota

Accepted for publication: October 10, 2000

Address for correspondence: LaDora V. Thompson, Department of Physical Medicine and Rehabilitation, Mayo MC 388, University of Minnesota, Minneapolis, MN 55455 (E-mail:

© 2001 Lippincott Williams & Wilkins, Inc.