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Complex Regional Pain Syndrome

Current Diagnostic and Treatment Considerations

Rand, Scott E. MD, FAAFP, CAQSM1,2; Basu, Sumana MD2; Khalid, Shoaib MD2

doi: 10.1249/JSR.0000000000000633
Extremity and Joint Conditions

Complex Regional Pain Syndrome is a severe complication of extremity fracture or other injury. Patients who develop this show marked hyperalgesia and allodynia, altered vasomotor, sudomotor and trophic changes. The condition affects women more than men and is most common in those between the ages of 50 and 70 years but can be seen in younger athletes. The diagnosis is made clinically, and treatment is directed at functional recovery using medications, occupational and physical therapy, and psychological interventions. Prognosis for complete recovery is variable and unpredictable.

1Houston Methodist Willowbrook Hospital

2Houston Methodist Orthopedics and Sports Medicine, Houston, TX

Address for correspondence: Scott E. Rand, MD, FAAFP, CAQSM, Houston Methodist Orthopedics and Sports Medicine, 13802 Centerfield Dr., Suite 300, Houston, TX 77070; E-mail:

Copyright © 2019 by the American College of Sports Medicine.