In inflammatory bowel disease, prolonged disease duration, pancolitis, histological inflammation, and subsequent dysplasia are associated with an increased risk for colorectal cancer. Recommendations regarding treatment of low-grade dysplasia (LGD) indicate an individualized approach between colectomy and surveillance. We present a unique case of a patient with ulcerative colitis who had multifocal LGD on 2 consecutive colonoscopies. However, after 10 years and 16 surveillance colonoscopies, she had no further evidence of dysplasia. This appears to be the first case of proven, permanently resolved multifocal LGD in inflammatory bowel disease that challenges our understanding of the natural history of LGD.
1Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA
2Crohns and Colitis Center of New Jersey, Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
3Philadelphia College of Osteopathic Medicine, Philadelphia, PA
4Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
5The Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
Correspondence: Steven R. Brant, MD, Rutgers Robert Wood Johnson Medical School, Crohns and Colitis Center of New Jersey, 1 RWJ Place, MEB 478B New Brunswick, NJ 08901 (Steven.Brant@rwjms.rutgers.edu).
Received February 13, 2019
Accepted June 24, 2019
Online date: September 21, 2019
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.