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Isolated Intestinal Angioedema Secondary to a Food Allergen

Hassan, Ammar DO1; Weissman, Simcha DO2; Sciarra, Michael A. DO1; Sotiriadis, John MD, PhD1

doi: 10.14309/crj.0000000000000222

ABSTRACT Intestinal angioedema is the dilatation or thickening, or both, of a segment of bowel. It is a diagnostic phenomenon that manifests itself clinically as acute abdominal pain, diarrhea, and emesis. Generally, this condition occurs in tandem with angioedema of the face and tongue and/or in association with the use of an angiotensin-converting enzyme inhibitor (ACE-I). We present a rare case of a 63-year-old woman who developed isolated intestinal angioedema due to the ingestion of a food allergen.

1Division of Gastroenterology and Hepatology, Hackensack University-Palisades Medical Center, North Bergen, NJ

2Department of Medicine, Hackensack University-Palisades Medical Center, North Bergen, NJ

Correspondence: Simcha Weissman, DO, Department of Medicine, Hackensack University-Palisades Medical Center, 7600 River Rd, North Bergen, NJ 07047 (

Received June 17, 2019

Accepted August 09, 2019

Online date: September 12, 2019

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Classically, angioedema has a large genetic component (C1-inhibitor deficiency) and can be associated with the use of an angiotensin-converting enzyme inhibitor (ACE-I).1,2 Additionally, the edema is usually located in the tongue and face or is at least concomitantly in the bowel as well.3 The bowel mucosa is rarely the only site of angiodema.1 Despite this, reports describing isolated intestinal angioedema do scantily appear in the literature. However, in most of these cases, the intestinal angioedema is secondary to the use of an ACE-I.

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A 63-year-old woman with no known medical history presented to the emergency room complaining of severe abdominal pain of acute onset. She mentioned that it occurred after drinking her daily green smoothie, after which she immediately developed severe abdominal cramping, nausea, vomiting, and watery diarrhea. She denied chest or back pain, blood in the stool, bloody emesis, facial or lip swelling, itching, or a rash. Upon further questioning, she mentioned the only addition to her normal morning smoothie was parsley. She remembered having a similar reaction years ago after ingesting kiwi fruit.

In the emergency room, she was febrile, tachycardic, and tachypneic. On physical examination, her abdomen was soft, nondistended, and tender to palpation, with normoactive bowel sounds throughout. Her laboratory results were notable for a white blood cell count of 18,000/mL and a lactate of 5.9 mmol/L. All other test results including blood cultures, stool analysis, erythrocyte sedimentation rate, cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA), perinuclear antineutrophil cytoplasmic antibodies (P-ANCA), C1-inhibitor, and complement levels were within normal limits. Computed tomography scan showed thickened bowel and submucosal edema, consistent with the diagnosis of isolated intestinal angioedema (Figure 1). She was given a 1-day course of antibiotics and antiemetics, after which her diet was advanced and soon after she was discharged home in the stable condition.

Figure 1

Figure 1

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Intestinal angioedema is marked tomographically by the dilatation and/or thickening of a segment of bowel.3 This occurs in response to an offending agent, which in our patient was the new vegetable.1 The most likely mechanism is immunoglobulin E-mediated mast cell degranulation releasing histamine leading to intestinal swelling.4 Any hollow viscera is prone to this type of temporary swelling. The severity of presentation of intestinal angioedema can vary, from mild colicky pain to severe vomiting and diarrhea.1 Generally this condition occurs in tandem with angioedema of the face and tongue.1 Moreover, nearly all cases are either genetic in nature due to a C1-inhibitor deficiency, which was not indicated in our case based on her normal C1-inhibitor levels, or associated with the use of an ACE-I, which acts as the offending agent.1,2,4,5 Intestinal angioedema rarely occurs secondary to the ingestion of a food allergen.

Avoidance of the trigger is the best form of prophylactic treatment. Edema can be reduced by the administration of antihistamines, glucocorticoids, epinephrine, or a combination of these medications. Interestingly, fresh frozen plasma has also shown efficacy in aborting acute attacks.6

In conclusion, physicians must remain mindful of this entity in patients presenting with acute abdominal pain, vomiting, or diarrhea of unknown etiology. Attention to imaging combined with a scrupulous history can help reach a diagnosis. Although most cases typically resolve within 1–3 days, early recognition may prevent unnecessary imaging as well as possible exploratory surgery.4

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Author contributions: A. Hassan and S. Weissman wrote and edited the manuscript. S. Weissman, A. Hassan, and MA Sciarra drafted and critically revised the manuscript. MA Sciarra and J. Sotiriadis provided images and edited the manuscript. S. Weissman and A. Hassan are the article guarantors.

Financial disclosure: None to report.

Informed consent was obtained for this case report.

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1. Bork K, Staubach P, Eckardt AJ, Hardt J. Symptoms, course, and complications of abdominal attacks in hereditary angioedema due to C1 inhibitor deficiency. Am J Gastroenterol. 2006;101:619–27.
2. Ciaccia D, Brazer SR, Baker ME. Acquired C1 esterase inhibitor deficiency causing intestinal angioedema: CT appearance. AJR Am J Roetgenol. 1993;161:1215–6.
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6. Nzeako UC. Diagnosis and management of angioedema with abdominal involvement: A gastroenterology perspective. World J Gastroenterol. 2010;16(39):4913–21.
© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.