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Strongyloides stercoralis Hyperinfection and Concomitant Cytomegalovirus Gastroenteritis in an Immunocompromised Host

Crowe, Brooks R. MD1; Duenas, Sean M. MD1; Serrano, Antonio MD2; Kingsbery, Joseph MD1; Williams, Renee MD1

doi: 10.14309/crj.0000000000000135
CASE REPORT
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ABSTRACT Strongyloides stercoralis infection typically presents with nonspecific gastrointestinal symptoms and no definitive or pathognomonic endoscopic findings. Disease burden can vary depending on a patient's immune status. Immunocompromised patients with strongyloidiasis can develop tremendous disease burden, extraintestinal dissemination, and are at risk for coinfection with other organisms. We present the case of an immunocompromised patient presenting with multiple gastrointestinal complaints found to have S. stercoralis hyperinfection and concomitant cytomegalovirus gastroenteritis.

1Department of Internal Medicine, New York University School of Medicine, New York, NY

2Department of Pathology, New York University School of Medicine, New York, NY

Correspondence: Renee Williams, MD, Division of Gastroenterology, NYU School of Medicine/Bellevue Hospital Center, 462 First Ave, 10N1, New York, NY 10016 (Renee.Williams@nyulangone.org).

Received October 31, 2018

Accepted May 13, 2019

Online date: July 15, 2019

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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INTRODUCTION

Strongyloides stercoralis infection often presents with nonspecific symptoms and a generally unrevealing endoscopic examination. However, because of the parasite's ability for autoinfection, immunocompromised hosts may present with tremendous disease burden and extraintestinal dissemination with multiorgan system failure. A high degree of suspicion should be maintained for S. stercoralis infection in immunocompromised patients from endemic areas with nonspecific gastrointestinal symptoms.

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CASE REPORT

A 59-year-old woman with no medical history presented with epigastric pain, odynophagia, hemoptysis, and weight loss. The patient was originally from Guyana and immigrated to the United States approximately 5 years before presentation. Blood work was significant for positive HIV antibody screen with a CD4 count of 52 cells/μL, normocytic anemia with hemoglobin 8.1 g/dL, and a normal white blood cell count without eosinophilia. Patient was ruled out for tuberculosis given hemoptysis.

She subsequently developed septic shock from multifocal pneumonia deemed secondary to aspiration and treated with broad-spectrum antibiotics. Blood cultures were positive for coagulase-negative Staphylococci species, which was deemed likely a contaminant. An abdominal computed tomography scan performed for epigastric pain and emesis revealed a small bowel obstruction that improved with bowel rest on repeat imaging. However, she continued to have persistent nausea and vomiting for which gastroenterology was consulted. An upper endoscopy revealed absent gastric motility and a thick white and green gastric and duodenal exudate with underlying friable and pale mucosa. Biopsies of the stomach and duodenum revealed an abundance of S. stercoralis filariform larvae within the epithelium. The duodenal biopsy showed an increase in neutrophils and plasma cells within the lamina propria in the epithelium surrounding the filariform larvae. In addition, there was blunting of the villous mucosa. Large intracytoplasmic inclusions were also seen and immunohistochemical stain specific for Cytomegalovirus (CMV) was positive (Figure 1). The patient was started on ivermectin and ganciclovir for S. stercoralis hyperinfection and CMV and initially showed mild symptomatic improvement. However, after several days, the patient developed septic shock despite broad-spectrum antibiotics and died.

Figure 1

Figure 1

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DISCUSSION

S. stercoralis is a nematode organism prevalent in tropical and subtropical regions and endemic to the southeastern region of the United States.1S. stercoralis can replicate entirely within the host creating an autoinfection cycle.2 Gastrointestinal symptoms tend to be nonspecific including diarrhea, weight loss, vomiting, melena, abdominal pain, nausea, and malabsorption.2 Stool samples are only intermittently positive with a single sample and often require multiple examinations.3 Endoscopy with gastric and duodenal biopsy sampling may aid in diagnosis.2 However, there appears to be no consistent findings on endoscopy with varying reports describing brown discoloration of the gastric or duodenal mucosa along with ulcerations or gastritis. Erythema, friability, aphthoid lesions, and ulcerations can also often be seen in the colon.1

Accelerated autoinfection leads to hyperinfection with a large increase in parasite burden and can lead to dissemination to organs outside of the pulmonary and gastrointestinal systems.4 In the developed world, corticosteroid use is the most common risk factor for hyperinfection.4,5 Steroid sparing immunosuppressants and human T-lymphotropic virus type 1 are also important causes of advanced disease.6

Although a CD4 count below 200 cells/μL has been associated with a higher rate of S. stercoralis infection, progression to hyperinfection and disseminated disease is uncommon in advanced HIV alone but can occur with steroid use or in the setting of immune reconstitution.4,7–10 HIV infection results in a greater loss of type 1 T helper cells compared with type 2 T helper cells, and type 2 T helper cells are involved in host defense against helminthic infections.8,11

Our case examines the profound gastrointestinal and extraintestinal complications from S. stercoralis and CMV coinfection in an HIV-positive patient. Because S. stercoralis infection can often present with a wide range of nonspecific symptoms and no definitive findings on endoscopy, suspicion should be maintained for patients who are immunocompromised, have disease risk factors, and no other clear etiology for symptoms. If suspicion for infection is high, patients should undergo endoscopy with gastric and duodenal biopsy and testing with multiple stool samples to confirm diagnosis. Testing for CMV should also be performed because it may predispose patients to further immunosuppression and exacerbate S. stercoralis in the setting of coinfection. Screening for infection should be considered in certain patients with a possible exposure history including transplant candidates and those patients requiring immunosuppression.4,12

This case represents a unique occurrence of Strongyloides hyperinfection in an HIV-positive patient due to the presence of CMV coinfection. To our knowledge, few cases of Strongyloides and CMV coinfection in immunocompromised patients have been discussed in the literature, and coinfection is often only identified at autopsy.13 Literature review revealed cases of S. stercoralis and CMV coinfection in a posttransplant patient and in a patient receiving chemotherapy for anaplastic large-cell lymphoma.13,14 A patient with undiagnosed human T-lymphotropic virus type 1 who developed fever, respiratory distress, and pulmonary hemorrhage after corticosteroid administration was subsequently found at autopsy to have disseminated strongyloidiasis as well as pulmonary CMV.15

An estimated 20% of patients with CD4 count under 100 cells/mm3 will develop CMV disease, and typically occurs if HIV viral load is >100,000 copies/mL.16 CMV gastrointestinal disease most commonly causes ulcers at the lower esophageal sphincter and can cause diffuse esophagitis, gastritis, and enteritis. Nongastrointestinal manifestations in HIV include retinitis, pneumonitis, and peripheral neuropathy.17 CMV has direct immunomodulatory properties in both immunocompetent and immunocompromised hosts that can lead to further immunosuppression and predispose patients to additional infections, which may have proved significant in this case.13,18–20

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DISCLOSURES

Author contributions: BR Crowe and SM Duenas wrote the manuscript and reviewed the literature. J. Kingsbery and R. Williams edited the manuscript. A. Serrano provided the pathology images. R. Williams is the article guarantor.

Financial disclosure: None to report.

Informed consent was obtained for this case report.

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REFERENCES

1. Thompson BF, Fry LC, Wells CD, et al. The spectrum of GI strongyloidiasis: An endoscopic-pathologic study. Gastrointest Endosc. 2004;59(7):906–10.
2. Overstreet K, Chen J, Wang Rodriguez J, Wiener G. Endoscopic and histopathologic findings of Strongyloides stercoralis infection in a patient with AIDS. Gastrointest Endosc. 2003;58(6):906–10.
3. Siddiqui AA, Berk SL. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis. 2001;33:1040–7.
4. Mejia R, Nutman TB. Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis. Curr Opin Infect Dis. 2012;25(4):458–63.
5. Marcos LA, Terashima A, Dupont HL, Gotuzzo E. Strongyloides hyperinfection syndrome: An emerging global infectious disease. Trans R Soc Trop Med Hyg. 2008;102:314–8.
6. Greaves D, Coggle S, Pollard C, Aliyu SH, Moore EM. Strongyloides stercoralis infection. BMJ. 2013;347:1–6.
7. Assefa S, Erko B, Medhin G, Assefa Z, Shimelis T. Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count. BMC Infect Dis. 2009;9:155.
8. Siegel MO, Simon GL. Is human immunodeficiency virus infection a risk factor for Strongyloides stercoralis hyperinfection and dissemination? PLoS Negl Trop Dis. 2012;6(7):e1581.
9. Brown M, Cartledge JD, Miller RF. Dissemination of Strongyloides stercoralis as an immune restoration phenomenon in an HIV-1-infected man on antiretroviral therapy. Int J STD AIDS. 2006;17:560–1.
10. Weatherhead JE, Mejia R. Immune response to infection with Strongyloides stercoralis in patients with infection and hyperinfection. Curr Trop Med Rep. 2014;1:229–33.
11. Aru RG, Chilcutt BM, Butt S, deShazo RD. Novel findings in HIV, immune reconstitution disease and Strongyloides stercoralis infection. Am J Med Sci. 2017;353(6):593–6.
12. Kassalik M, Mönkemüller K, Strongyloides stercoralis hyperinfection syndrome and disseminated disease. Gastroenterol Hepatol. 2011;7(11):766–8.
13. Elzein FE, Alsaeed M, Ballool S, Attia A. Strongyloides hyperinfection syndrome combined with cytomegalovirus Infection. Case Rep Transplant. 2016;2016:1786265.
14. Rehman JU, Rao TV, AlKindi S, Dennison D, Pathare AV. Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. Ann Hematol. 2007;86:925–6.
15. Sunagawa K, Nishio H, Kinukawa N, Yamada T, Nemoto N, Ochiai T. An autopsy case of disseminated strongyloidiasis combined with cytomegalovirus infection Jpn J Infect Dis. 2011;64:150–2.
16. Ross SA, Novak Z, Pati S, Boppana SB. Diagnosis of cytomegalovirus infections. Infect Disord Drug Targets. 2011;11(5):466–74.
17. Whitley RJ, Jacobson MA, Friedberg DN, et al. Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: Recommendations of an international panel. Arch Intern Med. 1998;158(9):957–69.
18. Ramanan P, Razonable RR. Cytomegalovirus infections in solid organ transplantation: A review. Infect Chemother. 2013;45(3):260–71.
19. Freeman RB Jr. The “indirect” effects of cytomegalovirus infection. Am J Transpl. 2009;9(11):2453–8.
20. Varani S, Frascaroli G, Landini MP, Söderberg-Nauclér C. Human cytomegalovirus targets different subsets of antigen-presenting cells with pathological consequences for host immunity: Implications for immunosuppression, chronic inflammation and autoimmunity. Rev Med Virol. 2009;19(3):131–45.
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