Polyploid karyotypes in diffuse large B-cell lymphoma (DLBCL) are rare and carry a poor prognosis. Extranodal polyploid lymphoma is uncommon. A 71-year-old man with back pain was found to have ileal intussusception. He underwent surgical resection and was diagnosed with DLBCL with a near-tetraploid karyotype. Despite rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy, he developed recurrent disease for which he started a clinical trial. He then developed dark stools from an ileal ulcer due to progressive disease and died 2 weeks later. This is the first reported case of gastrointestinal DLBCL with polyploidy. These karyotypes require attention to extranodal disease and prompt initiation of therapy.
1Division of Gastroenterology and Hepatology, New York Presbyterian/Weill Cornell Medical Center, New York, NY
2Department of Pathology and Laboratory Medicine, New York-Presbyterian/Weill Cornell Medical Center, New York, NY
3Division of Hematology and Medical Oncology, New York Presbyterian/Weill Cornell Medical Center, New York, NY
Correspondence: Steven N. Mathews, MD, Division of Gastroenterology and Hepatology, New York Presbyterian/Weill Cornell Medical Center, New York, NY 10065 (firstname.lastname@example.org).
Received November 07, 2018
Accepted March 27, 2019
Online date: July 17, 2019
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