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Black Seed Oil and Perioperative Serotonin Syndrome: A Case Report

Warner, Mary E. MD; Warner, Paul A. MD; Sprung, Juraj MD, PhD; Warner, Mark A. MD

doi: 10.1213/XAA.0000000000001096
Case Reports

Perioperative serotonin syndrome has been associated with a number of medications and herbal supplements. We report a patient who developed serotonin syndrome immediately after an endoscopic procedure in which the preoperative use of black seed oil appears to have played a role in stimulating the syndrome. Black seed oil has not been previously reported in association with perioperative serotonin syndrome. Anesthesia professionals should be aware that patients taking black seed oil supplements may develop serotonin syndrome postoperatively.

From the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Accepted for publication August 20, 2019.

Funding: None

The authors declare no conflicts of interest.

Address correspondence to Mary E. Warner, MD, Department of Anesthesiology, Mayo Clinic, 1-145 Charlton Bldg, 200 First St SW, Rochester, MN 55905. Address e-mail to

Copyright © 2019 International Anesthesia Research Society
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