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Efficacy of Sugammadex in Preventing Skin Test Reaction in a Patient With Confirmed Rocuronium Anaphylaxis: A Case Report

Binczak, Marie MD*; Fischler, Marc MD*,†; Le Guen, Morgan MD, PhD*,†

doi: 10.1213/XAA.0000000000000973
Case Reports

The curative role of sugammadex has been challenged in several observations of rocuronium-induced anaphylaxis because sugammadex may not completely encapsulate the molecule of rocuronium. In such conditions, rocuronium remains able to cause immunoglobulin E cross-linkage and the anaphylaxis mechanism can continue. We describe a case of rocuronium-induced anaphylaxis in which clinical improvement followed sugammadex administration. Intradermic skin tests confirmed rocuronium immunoglobulin E–mediated anaphylaxis but also showed intradermal injection of mixing in equal molecular ratio of sugammadex with rocuronium preventing rocuronium anaphylactic skin reaction. This observation demonstrates the efficacy of sugammadex to prevent rocuronium interaction with the skin immune system.

From the *Department of Anesthesiology, Hospital Foch, Suresnes, France

University Versailles Saint-Quentin en Yvelines, France.

Accepted for publication December 21, 2018.

Funding: Support was provided by the Department of Anesthesiology, Hospital Foch, Suresnes, France.

The authors declare no conflicts of interest.

Address correspondence to Marc Fischler, MD, Department of Anesthesiology, Hospital Foch, 40 rue Worth, Suresnes, France. Address e-mail to

Copyright © 2019 International Anesthesia Research Society
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