In this case report, we describe 2 patients with septic shock requiring high-dose vasopressors for hemodynamic support despite aggressive fluid resuscitation. After the administration of high-dose hydroxocobalamin for presumed septic vasoplegic syndrome, both patients had an immediate response to hydroxocobalamin with a rapid and lasting improvement of blood pressure that significantly reduced the need for vasopressor support.
From the *Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, California
†Department of Anesthesiology and Perioperative Care, University of California Irvine Health Orange, California.
Accepted for publication October 8, 2018.
The authors declare no conflicts of interest.
Address correspondence to Trung Q. Vu, MD, Department of Anesthesiology and Perioperative Care, University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 82868. Address e-mail to email@example.com.