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The Use of Nitric Oxide in Patients With Obstructed Pulmonary Veins

A Case Report

Sokoliuk, Victoria, DO; DiNardo, James A., MD; Brown, Morgan L., MD

doi: 10.1213/XAA.0000000000000885
Case Reports

Pulmonary vein stenosis (PVS) is a progressive disease with pulmonary hypertension (PH) as a major cause of morbidity and mortality. Traditional management of PH with inhaled nitric oxide (iNO) is typically avoided in PVS patients because, while iNO may reduce pulmonary vascular resistance, PH persists as pulmonary blood flow increases in the presence of a downstream resistive lesion. We report 3 cases with primary PVS and PH in which iNO was used to successfully decrease mean pulmonary artery pressures with clinical improvement. Based on this experience, we suggest that iNO can be used to treat PH in select patients with PVS.

From the Department of Cardiac Anesthesia, Boston Children’s Hospital, Boston, Massachusetts.

Accepted for publication July 27, 2018

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Morgan L. Brown, MD, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA 02446. Address e-mail to

© 2019 International Anesthesia Research Society
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