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Complete Nephrogenic Diabetes Insipidus After Prolonged Sevoflurane Sedation: A Case Report of 3 Cases

Cabibel, Rodolphe MD*; Gerard, Ludovic MD*; Maiter, Dominique MD, PhD; Collin, Vincent MD; Hantson, Philippe MD, PhD*

doi: 10.1213/XAA.0000000000000871
Case Reports

Volatile anesthetic agents, such as sevoflurane, are increasingly used for long-term sedation in intensive care units worldwide, with improved clinical outcomes reported in recent studies due to favorable pharmacological properties. Despite possible renal toxicity related to the production of plasma inorganic fluoride and concerns related to reversible impairment of renal concentrating abilities, renal injury associated with sevoflurane sedation has rarely been reported in the intensive care unit setting. We hereby report 3 cases of nephrogenic diabetes insipidus associated with prolonged sevoflurane sedation using the AnaConDa device and review the possible mechanisms of renal toxicity.

From the Departments of *Intensive Care

Endocrinology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

Department of Intensive Care, Cliniques de l’Europe, Brussels, Belgium.

Accepted for publication July 12, 2018.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Philippe Hantson, MD, PhD, Department of Intensive Care, Cliniques Universitaires Saint-Luc, Av Hippocrate 10, 1200 Brussels, Belgium. Address e-mail to

Copyright © 2018 International Anesthesia Research Society
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