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Dexmedetomidine-Induced Massive Diuresis in a Patient Undergoing Spinal Fusion Surgery

A Case Report and Synthesis of the Literature

Kirschen, Gregory W., PhD*; Kim, Ethan, MD; Adsumelli, Rishimani S. N., MD

doi: 10.1213/XAA.0000000000000860
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Dexmedetomidine is an α2-adrenergic sedative–hypnotic medication used as an adjunct to general anesthesia. While experimental studies in animals have demonstrated a mild diuretic effect of dexmedetomidine, only recently have case reports described dexmedetomidine-induced diuresis in humans. Interestingly, the majority of such cases have involved patients undergoing spinal fusion surgery. Here, we report a case of a 30-year-old woman undergoing cervical spinal fusion surgery who experienced a massive diuresis starting 30 minutes after receiving dexmedetomidine intravenous infusion. We discuss the differential diagnosis and synthesize the current literature on this rare effect.

From the *Medical Scientist Training Program (MSTP), Stony Brook University School of Medicine, Stony Brook, New York

Department of Anesthesia, Stony Brook University School of Medicine, Stony Brook, New York.

Accepted for publication June 29, 2018.

Funding: None.

The authors declare no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website.

Address correspondence to Rishimani S. N. Adsumelli, MD, Department of Anesthesia, Stony Brook University School of Medicine, 101 Nicolls Rd, Stony Brook, NY 11794. Address e-mail to Rishimani.Adsumelli@stonybrookmedicine.edu.

© 2019 International Anesthesia Research Society
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