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Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient

A Case Report

Sanoja, Ivanna A., MD; Toth, Kenneth S., MD, PhD

doi: 10.1213/XAA.0000000000000834
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We report the case of a 60-year-old man who underwent open radical prostatectomy for prostate adenocarcinoma. He had no known cardiac disease or symptoms other than controlled hypertension and remote history of cocaine use. The patient was given sugammadex for reversal of neuromuscular blockade and, within 1 minute, developed severe, drug-resistant bradycardia followed by pulseless electrical activity arrest. Advanced cardiac life support was initiated and continued for 15 minutes before the return of spontaneous circulation. Subsequent cardiac workup showed no abnormalities. We believe the cause of arrest was sugammadex, considering the time of administration, the absence of cardiac disease, and stable operative course.

From the Department of Anesthesiology and Pain Management, John H. Stroger Jr. Hospital of Cook County, Chicago Illinois.

Accepted for publication May 24, 2018.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Ivanna A. Sanoja, MD, Department of Anesthesiology and Pain Management, John H. Stroger Jr. Hospital of Cook County, 1969 Ogden Ave, Chicago, IL 60612. Address e-mail to isanoja@cookcountyhhs.org.

© 2019 International Anesthesia Research Society
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