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Osteopetrosis—Anesthetic Considerations for Total Knee Arthroplasty

A Case Report

Soberón, José R. Jr, MD*; Arzillo, Samantha, MD; Myers, Scott L., MD; King, Joseph J., MD

doi: 10.1213/XAA.0000000000000828
Case Reports

Autosomal dominant or benign osteopetrosis is a rare genetic disorder of osteoclasts that results in dense but brittle bone structures. Patients with osteopetrosis may be scheduled for total knee arthroplasty to treat painful and functionally limiting osteoarthrosis. A search of the published literature produced no citation concerning anesthesia for patients with autosomal dominant osteopetrosis undergoing total knee arthroplasty. We present a case report detailing our experience and discuss considerations for the care of future patients with autosomal dominant osteopetrosis.

From the *Department of Anesthesiology, North Florida/Southern Georgia Veterans Health System

Department of Anesthesiology

Department of Orthopedic Surgery, North Florida/Southern Georgia Veterans Health System and the University of Florida College of Medicine, Gainesville, Florida.

Accepted for publication May 14, 2018.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to José R. Soberon Jr, MD, Department of Anesthesiology, Malcom Randall VA Medical Center, 1601 Archer Rd, Gainesville, FL 32608. Address e-mail to

© 2019 International Anesthesia Research Society
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