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Anesthetic Management of Two Pediatric Patients With Concurrent Diagnoses of Mitochondrial Disease and Malignant Hyperthermia Susceptibility: A Case Report

Nelson, Jonathon H. MD; Kaplan, Richard F. MD

doi: 10.1213/XAA.0000000000000565
Case Reports: Case Report

We report the case of 2 pediatric patients with coexisting diagnoses of malignant hyperthermia susceptibility and mitochondrial disease in 2 different surgical settings. Due to the rare occurrence of each disorder, and even more so together, we reviewed evidence-based anesthetic concerns and described our perioperative management, with the goal of aiding future practitioners in safely caring for these patients. Consent was obtained for both patients, as well as IRB approval before publication.

From the Division of Anesthesiology and Pain Medicine, Children’s National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC.

Accepted for publication March 27, 2017.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Jonathon H. Nelson, MD, Division of Anesthesiology and Pain Medicine, Children’s National Health System, 111 Michigan Ave NW, Washington, DC 20010. Address e-mail to

© 2017 International Anesthesia Research Society
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