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Whether to Proceed With Deep Brain Stimulator Battery Change in a Patient With Signs of Potential Sepsis and Parkinson Hyperpyrexia Syndrome: A Case Report

Liu, Chyong-jy Joyce DO; Crnkovic, Anica MD; Dalfino, John MD; Singh, Leina Yoko MD

doi: 10.1213/XAA.0000000000000462
Case Reports: Case Report

Parkinsonism-hyperpyrexia syndrome (PHS) is a neurologic emergency associated with anti- Parkinson medication withdrawal; however, its clinical presentation mimics sepsis. We describe the case of a 69-year-old man with advanced Parkinson disease who presented for exchange of the depleted battery in his subthalamic deep brain stimulator. The patient’s preoperative symptoms of fever, rigidity, altered consciousness, and autonomic instability presented a dilemma whether to proceed with battery exchange to treat PHS or postpone surgery due to potential sepsis. The administration of dopaminergic medications, dantrolene, and antipyretic drugs are temporary supportive measures, while prompt restoration of deep brain stimulator function is the most important therapeutic treatment for PHS.

From the Departments of *Anesthesiology; Neurosurgery; and Pediatrics, Albany Medical Center, Albany, New York.

Accepted for publication October 12, 2016.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Chyong-jy Joyce Liu, DO, Department of Anesthesiology, Albany Medical Center, 47 New Scotland Ave, M/C 131, Albany, NY 12208. Address e-mail to

© 2017 International Anesthesia Research Society
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