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Fulminant Intraoperative Right Heart and Pulmonary Artery Thrombosis Following Prothrombin Complex Concentrate Infusion after Complex Open Heart Surgery with Cardiopulmonary Bypass

Koster, Andreas MD; Meyer-Jark, Ties MD; Schirmer, Uwe MD; Sandica, Eugene MD

doi: 10.1097/ACC.0b013e3182a070e9
Case Reports: Case Report

Prothrombin complex concentrates are increasingly used during complex cardiac surgery with cardiopulmonary bypass. Reports describing massive thromboembolism after administration of prothrombin complex concentrates are rare. We report a case of a patient developing massive intracardiac and pulmonary artery thrombus formations during infusion of a moderate dose of prothrombin complex concentrate after separation from cardiopulmonary bypass for complex open heart surgery.

From the Institute of Anesthesiology and Department for Surgery of Congenital Heart Disease, Heart and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany.

Accepted for publication May 31, 2013.

Funding: No funding.

The authors declare no conflicts of interest.

Address correspondence to Andreas Koster, MD, Institute of Anesthesiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Georgstr. 11, D-32545, Bad Oeynhausen Germany. Address e-mail to

© 2014 International Anesthesia Research Society