Medical Gas Research

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​About the Journal

Founded in 2011, Medical Gas Research (MGR; ISSN 2045-9912) is an international, peer-reviewed, open-accessed journal ( published quarterly, with its mission focused on reporting high quality and novel scientific advancements in the field of medical gas research. The journal is committed to publishing articles on original experimental and clinical research, technological advances and methods, and expert reviews realted to medical gas research.

MGR has been indexed by Emerging Sources Citation Index (ESCI), PubMed, SCOPUS and other major international indexing systems. We hope that, with your support, MGR will become a highly recognized journal in the field of medical gas.

Aims and Scopes

MGR is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas and their applications to related disorders.

Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, MGR will serve as an information platform for educational and technological advances in the field of medical gas.

MGR also covers molecular actions in neurological diseases, as well as the pre-clinical and clinical applications of the above named gases in relation to these disorders. The journal particularly welcomes novel approaches to translate scientific discoveries from basic medical gas research, into the development of new strategies for the prevention, assessment and treatment of clinical medical gas application.


MGR has a strong international focus on neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders.

Abstracting and Indexing

  • Emerging Sources Citation Index (ESCI)
  • PubMed
  • PubMed Central (PMC)
  • Scimago Journal Ranking (SJR)
  • DOAJ
  • Baidu Scholar
  • China National Knowledge Infrastructure (CNKI)
  • Index of Copurnicus (IC)
  • EBSCO Publishing's Electronic Databases
  • Exlibris – Primo Central
  • Google Scholar
  • Hinari
  • Infotrieve
  • National Science Library
  • ProQuest
  • TdNet

Editorial Board


John H. Zhang, Professor, Departments of Anesthesiology, Physiology, Neurosurgery and Neurology, Loma Linda University, USA.

Section Editors


Mark Coburn, M.D.

Department of Anaesthesiology,

University Hospital Aachen, Germany

Robert Ostrowski, M.D., Ph.D.

Department of Experimental and Clinical Neuropathology,

Mossakowski Medical Research Centre, Polish Academy of Sciences, Poland


Gang Chen, M.D., Ph.D.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, China

Atsunori Nakao, M.D.

Okayama University, Japan

Xuejun Sun, M.D., Ph.D.

Department of Navy Aeromedicine, Faculty of Naval Medicine, The Second Military Medical University, China


Richard L. Applegate, M.D.

Professor and Chair

Department of Anesthesiology and Pain Medicine, Loma Linda University, USA

John Calvert, Ph.D.

Assistant Professor of Surgery

Cardiothoracic Research Laboratory, Department of Surgery,

Emory University School of Medicine, USA

Ke Jian “Jim" Liu, Ph.D.


Associate Dean for Research Director, UNM Brain Imaging Center Health Sciences Center, The University of New Mexico, USA

Dan Rossignol, M.D., FAAFP

International Child Development Resource Center, USA

Zhongcong Xie, M.D., Ph.D.

Department of Anesthesia, Critical Care & Pain Medicine,

Massachusetts General Hospital, USA

Shaohua Yang, M.D., Ph.D.

Professor and Associate Director

Department of Pharmacology,

University of North Texas, USA

Clinical Study: Richard Applegate, Gang Chen, Mark Cohurn, Atsunori Nakao, Dan Rossignol, Zhongcong Xie

Basic Science Study: John Calvert, Jim Liu, Shaohua Yang, Robert Ostrowski, Xuejun Sun

Inert Gases Section: Xuejun Sun, Mark Coburn

Gasotransmitters Section: Atsunori Nakao, John Calvert

Oxygen and Diving Medicine Section: Daniel Rossignol, Jim Liu

Anesthetic Gases Section: Richard Applegate, Zhongcong Xie

Medical Gas in Other Fields Section: Shaohua Yang, Robert Ostrowski

Editorial Board Members

The editorial board of 47 menbers led by Prof. Zhang comprises the members who are dedicated to developing a journal presenting outstanding peer-reviewed, evidence-based scholarly research in medical gas.

Full list of Editorial Board Members could be found at

Criteria for Publication

  • The study presents the results of primary scientific research.
  • Experiments, statistics, and other analyses are performed to a high technical standard and are described in sufficient detail.
  • Results reported have not been published elsewhere.
  • Conclusions are presented in an appropriate fashion and are supported by the data.
  • The research meets all applicable standards for the ethics of experimentation and research integrity.
  • The article adheres to appropriate reporting guidelines and community standards for data availability.
  • The article is presented in an intelligible fashion and is written in Standard English.

Editorial policy

Editorial Process
A manuscript will be reviewed for possible publication with the understanding that it is being submitted to Medical Gas Research alone at that point in time and has not been published anywhere, simultaneously submitted, or already accepted for publication elsewhere. The journal expects that authors would authorize one of them to correspond with the Journal for all matters related to the manuscript. All manuscripts received are duly acknowledged. On submission, editors review all submitted manuscripts initially for suitability for formal review. Manuscripts with insufficient originality, serious scientific or technical flaws, or lack of a significant message are rejected before proceeding for formal peer-review. Manuscripts that are unlikely to be of interest to Medical Gas Research's readers are also liable to be rejected at this stage itself.

Manuscripts that are found suitable for publication in Medical Gas Research are sent to two or more expert reviewers. During submission, the contributor is requested to provide names of two or three qualified reviewers who have had experience in the subject of the submitted manuscript, but this is not mandatory. The reviewers should not be affiliated with the same institutes as the contributor/s. However, the selection of these reviewers is at the sole discretion of the editor. The journal follows a double-blind review process, wherein the reviewers and authors are unaware of each other's identity. Every manuscript is also assigned to a member of the editorial team, who based on the comments from the reviewers takes a final decision on the manuscript. The comments and suggestions (acceptance/ rejection/ amendments in manuscript) received from reviewers are conveyed to the corresponding author. If required, the author is requested to provide a point by point response to reviewers' comments and submit a revised version of the manuscript. This process is repeated till reviewers and editors are satisfied with the manuscript.

Manuscripts accepted for publication are copy edited for grammar, punctuation, print style, and format. Page proofs are sent to the corresponding author. The corresponding author is expected to return the corrected proofs within three days. It may not be possible to incorporate corrections received after that period. The whole process of submission of the manuscript to final decision and sending and receiving proofs is completed online. To achieve faster and greater dissemination of knowledge and information, the journal publishes articles online as 'Ahead of Print' immediately on acceptance.

Peer review policy

Rigorous Peer Review
Referees of MGR are asked to evaluate the manuscript of technically sound. Judgments about the significance of any particular paper are made after publication by the readership, who are the most qualified to determine what is of interest to them.

Peer Review Process
Once the manuscript has passed quality control, it is assigned to the strict double-blinded peer review process for a decision, either to accept, revise, or reject the article.

The majority of MGR submissions are evaluated by 3–5 external reviewers. Average time from the submission to the first editorial decision is 1 month. The review time could be shortened to 7 days for the paper with sophisticated comments from other recognized journals in the file. According to these comments, the academic editors will make a decision as to accept, reject, request a revision or send to another peer review. Authors who receive a decision of Minor Revision or Major Revision have 21 days to resubmit the revised manuscript.

If you are submitting a revised manuscript, the following items with your revised submission are required:

  • Response to reviewers form: Address the specific points made by each reviewer.
  • Revised manuscript (traced copy): Include a traced copy of your manuscript file showing the changes you have made on the original submission.
  • Revised manuscript (clean copy): Upload a clean copy of your revised manuscript that does not show your changes.

Manuscripts received from Editorial Board members will be screened by the Editor-in-Chief and sent to external peer reviewers. In case, Editor-in-chief is the author, then the article will be screened by Assistant editor/co-editor in chief and sent to external peer reviewers. The editorial board members who are authors will be excluded from publication decisions.

Reviewer Recognition
The quality of MGR depends on the effort that is generously contributed by our reviewers who have dedicated their expertise and time helping to ensure we publish great science. Special thanks go out to an outstanding group of reviewers who have provided an extraordinary number of thoughtful reviews along with frequent reviewers who have reviewed four or more manuscripts each year.

We encourage the reviewers to share and discuss their review comments on Publons ( MGR will also give credit to registered reviewers on Publons.

Appeal Procedure

The authors do have the right to appeal if they have a genuine cause to believe that the editorial board has wrongly rejected the paper. If the authors wish to appeal the decision, they should email the editorial office ([email protected]) explaining in detail the reason for the appeal. The appeals will be acknowledged by the editorial office and will be investigated in an unbiased manner. The processing of appeals will be done within 6–8 weeks. While under appeal, the said manuscript should not be submitted to other journals. The final decision rests with the Editor-in-Chief of the journal. Second appeals are not considered.

Submission Guidelines

Manuscripts should be submitted online at

Cover letter

Authors are required to declare the following statements, including:

  • The manuscript is original, has not been submitted to or is not under consideration by another publication and has not been previously published in any language or any form, including electronic.
  • All authors approve the final version of the manuscript and of its submission to MGR.
  • Recommending 3–5 scientists as peer reviewers for your manuscript, including their contact information. The suggested reviewers should be in the same field of your study, and from different institutions and have not copublished articles previously.
  • Once submitted to MGR, the manuscript should not be submitted to other journals within 1 month, whether it is undergoing or awaiting the paper review process.

Update your ORCID record after publication

The first author or the corresponding author should provide ORCID upon manuscript submission to facilitate accurate author publication data maintained by journal or database statisticians.

Transfer of copyright agreement

Once your paper is successfully submitted, publishing agreements should be signed by all authors and uploaded to the editorial system.

Article type

  • Research Articles: reports of data from original research.
  • Review: comprehensive, authoritative, descriptions of any subject within the journal's scope. Reviews can cover any topical themes such as basic science and clinical reviews, ethics, pro/con debates, equipment reviews and thematic series to highlight specific topics in the field.
  • Short Communication: brief reports of data from original research, usually about 1,500 words.
  • Case Report: reports of clinical cases that can be educational, describe a diagnostic or therapeutic dilemma, suggest an association, or present an important adverse reaction.
  • Commentary: short, focused and opinionated articles on any subject within the journal's scope. These articles focus on specific issues and are about 800 words.
  • Letter to the Editor: these can take three forms: a substantial re-analysis of a previously published article, or a substantial response to such a re-analysis from the authors of theoriginal publication, or an article that may not cover “standard research" but that may be relevant toreaders.

Acceptance and Publication

After acceptance, the authors are free inquiry inquiries regarding the progress of their manuscript submitted online using the account number assigned to the corresponding author at any time. Generally, manuscripts will be published within 3–6 months after revision.


Acceptance rate

The acceptance rate of MGR was 35% in 2019.

Ethical Guidance

According to ICMJE recommendations, the authors should follow all ethical principles for medical research involving humans and experimental animals.

Requirements for ethical issues related to animal experimentsm

  • Medical researchers should abide by international guidelines for the care and use of laboratory animals, the Weatherall report on the use of non-human primates in research (2006), and The National Centre for the Replacement, Refinement and Reduction of Animals in Re-search (NC3Rs).
  • The authors' institutional animal care and use committee that approved the animal experiments and the associated permit number(s) should be stated in research papers.
  • The methods section of MGR papers must include ethics statements, e.g. “The protocol was approved by the Animal Ethics Committee of XXX University (approval number: XXX). All surgery was performed under sodium pentobarbital anesthesia, and all efforts were made to minimize animal pain, distress, and death." Guidelines for euthanasia methods approved by MGR for use in animal experiments is shown in [Table 1].

Table 1: Examples of Data Sharing Statements that Fulfill these ICMJE Requirements*

  • Data and methods published in MGR should be shared for replication of the results by others. Original experimental data or DOI numbers registered in data repository should be provided upon submission to facilitate understanding of peer reviewers and transparency to other audiences.
  • Original data from studies involving genes, proteins, mutants and diseases should be registered on recognized public databases e.g. figshare or re3data, and the registered identifier should be provided upon submission.
  • A small amount of data or certain special data may be submitted as supplementary data online.
  • For data mining from other open-access databases, the source must be indicated.
  • Studies involving animal experiments should be reported according to ARRIVE guidelines (

Requirements for ethical issues related to clinical trials

  • All studies performed involving human should be registered in clinical trials registry platform, such as, prior to participant recruitment. The registry platform and register identifier should be provided upon submission and included in the abstract of the manuscript.
  • The ethics committee and the approval number(s) should be stated in papers. Prospective clinical studies with no registration will not be accepted by MGR. In addition, informed consent of study and protocol verion should be indicated.
  • Clinical manuscripts should be written according to the reporting guidelines at Additionally, checklists and a flow chart should be provided upon submission.


Research ethics policy

Human and Animal Rights

When reporting experiments on human subjects, authors should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national). If doubt exists whether the research was conducted in accordance with the ethical standards, the authors must explain the rationale for their approach, and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. When reporting experiments on animals, authors should be asked to indicate whether the institutional and national guide for the care and use of laboratory animals was followed.


Informed consent policy

 Protection of Patients' Rights to Privacy 

Identifying information should not be published in written descriptions, photographs, sonograms, CT scans, etc., and pedigrees unless the information is essential for scientific purposes and the patient (or parent or guardian, wherever applicable) gives written informed consent for publication. Authors should remove patients' names from figures unless they have obtained written informed consent from the patients. When informed consent has been obtained, it should be indicated in the article and copy of the consent should be attached with the covering letter.



  • Each MGR paper will be checked twice, using Crosscheck to verify originality after submission and prior to publication. The check report will be sent to the authors.
  • The similarity of any MGR paper should not be over 5% against one single published paper, nor over 20% against all published papers.
  • Similarity between new submitted manuscript and the published by the same research team or author should be not over 50%.
  • No retracted articles should be cited.
  • For dishonorable events including redundant (duplicate) publication, suspected plagiarism, and undisclosed conflicts of interest, MGR will abide by the regulations suggested by COPE guidelines (

Corrections and Retractions

  • MGR publishes corrections, retractions, and expressions of concern as appropriate, and as quickly as possible. We follow the ICMJE and COPE guidelines where applicable.
  • Correction: A notice of correction will be issued by MGR to correct substantial errors that appear in published articles when these errors significantly affect the content or understanding of the work (e.g., error in data presentation or analysis) or when the error affects the publication's metadata (e.g., misspelling of an author's name). In these cases, MGR will publish a correction that will be linked to the original article. In very rare cases, we may choose to correct the article itself and repost it online. If that course is taken, a correction notice will also be created to document the changes to the original article.
  • Author-Initiated Retractions: MGR will retract an article at the authors' request at any time unless it is under review for a possible violation of Responsible Conduct Regarding Scientific Communications. At the authors' option, the retraction notice may simply state that the article has been retracted at the authors' request. Alternatively, the authors may provide a brief explanation of the error(s) prompting the retraction. However, statements of retraction may not assign blame to specific authors or laboratories.
  • Retractions: The editors reserve the right to retract an article at any time after publication without the consent of the authors if an investigation by an appropriate authority reveals a violation of MGR's Ethics Policy.
  • To request a correction/retraction, please contact the editorial office directly at [email protected].

Data Availability

MGR encourages authors to upload original experimental data on journal website or Figshare prior to or after publication, including original data, images, or tables. Open access of data will increase study transparency, accelerate the scientific research pace, and establish crediblity of scientific research.

Figshare is an internationally respected data repository that can upload, store, and share original data of the study. With the permission of open-access copyright, the authors can display and share their data, which facilitates retrieval, reading, download, and sharing.

Data Sharing Statement in Clinical Trials

As of 1 June 2018, manuscripts submitted to MGR that report the results of clinical trials must contain a data-sharing statement as described in [Table 1]

Open-Access Publication

MGR is co-published by Wolters Kluwer-MedKnow, a global open access medical publisher. Therefore, MGR applies the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License to works we publish. This license allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Anyone interested in reading your research can get free access to your paper at our offical website ( or PubMed Central.

Open Access Service Fees

Authors of published papers will be granted complete waiver for the open-access fee.


Reprints can be purchased as print reprints and as translated articles, and will be customized to your specific requirements and shrink-wrapped.

Dissemination after Publication

Once the paper is published, it will be scheduled for dissemination via e-Newslettter.

After publication, the papers online can be rapidly retrieved and exposed via Web of Science, Google Scholar, Pubmed, Pubmed Central.

Copyright/Permissions after Publication

  • The publisher retains all rights concerning assembling, printing, reproducing, translating, disseminating, exhibiting, publishing, retrieving and indexing part or all of the contents of the article.
  • After signing transfer of copyright with the journal, the authors retain the rights.
  • In not-for-profit circumstances, the use, dissemination and reproduction of part or all of the contents of the article is permitted when cited appropriately.


Advertising policy

  • All advertisements are subject to approval of the Publisher, or Editor. However, the Publisher or the Editor shall not unreasonably withhold such approval. 
  • Advertising is separate from content. Advertisers and sponsors have no advance knowledge of our editorial content, nor do the editors shape content to accommodate advertising. Publisher will not sell advertising for a specific product on the condition that it appear in the same location, and at the same time, as a specific article mentioning that product, unless clearly labeled as an exclusive sponsor. Advertisers do not influence any of our editorial decisions or advertising policies. 
  •  The appearance of advertising on our journal is neither a guarantee nor an endorsement by the publisher, society or editorial partner of the product, service, or company and claims made in such advertising. 
  •  Advertising that appears at Publisher's journal will be clearly distinguishable from editorial content. 
  • Publisher's advertising sales representatives have neither control over, nor prior knowledge of, specific editorial content before it is published. 
  • Advertisers have no control or influence over the results of searches a user may conduct on the Publisher's journal. Search results are based solely on the functionality available through our search software (e.g., keywords or natural language) and user-defined criteria (e.g., displaying most recent or most relevant items first). 
  • All advertisements are accepted and published by Publisher on the warranty of the agency and advertiser that both are authorized to publish the entire contents and subject matter of the advertisement. 
  •  In consideration of publication of an advertisement, the advertiser and the agency, jointly and severally, agree to indemnify and hold harmless Publisher, its officers, agents and employees against expenses (including legal fees) and losses resulting from the publication of the contents of the advertisement, including, without limitation, claims or suits  for libel, violation of privacy, copyright infringement or plagiarism. 
  • All advertisements must clearly and prominently identify the advertiser by trademark or signature. 
  • Any reference to Publisher or it products or services in advertisements, promotional material, or merchandising by the advertiser or the agency is subject to the Publisher's prior written approval for each such use. 
  • Publisher is not responsible for any damages, including but not limited to actual, direct, incidental or consequential damages, for errors in displaying an ad. 
  • Publisher will not be bound by any condition, printed or otherwise, appearing on any insertion order or copy instructions when such conditions conflict with the conditions set forth in this policy statement.
  • In the event of nonpayment, Publisher reserves the right to hold advertiser and/or its advertising agency liable for such monies as are due and payable to Publisher. 
  • Any use of Publication trademarks or copyrighted material for links to and from the website must be approved, inadvance, by the Publisher.  Any such unauthorized linking is prohibited. 
  • Recruitment ads: All advertisements for employment must be nondiscriminatory and comply with all applicable laws and regulations. Ads that discriminate against applicants based on sex, age, race, religion, marital status, or physical handicap will not be accepted. Non-US recruitment advertisers are required to confirm in writing that they are equal opportunity employers. 
  • Advertised products must be compliant with the regulations in the country where the advertisement will be seen. 
  • Publisher does not release personally identifiable data on the users of our websites or email service to advertisers.

    Contact Us

    Journal website: http://www.

    Submission website:

    Telephone: +86(24)23380576/ +86-13804998773

    By Mail: Shenyang PO Box 10001, Shenyang 110180, Liaoning Province, P. R. China

    Author inquiries: [email protected]

Formatting Guidelines

Research Article

  • Word limit: 4,000-6,000 words, 8-10 published pages.
  • Title: 90 characters (20 words) maximum.
  • Abstract: 250 words maximum, unstructured abstract.
  • Graphical abstract:
  • Introduction: 1,000 words maximum.
  • Materials/Subjects and Methods:
  • Results:
  • Discussion: 1,000 words maximum.
  • Acknowledgments:
  • Declaration of patient consent (only for clinical studies):
  • Author contributions:
  • Conflicts of interest:
  • Financial support:
  • References: 50 minimum; 30% of cited references should have been published within the preceding 3 years; use the reference style of American Medical Association (AMA) Citaxion Style.


  • Word limit: 6,000 words minimum including the abstract, but excluding references, tables and figures. 8-10 published pages.
  • Structure:
  • Title: 90 characters (20 words) maximum.
  • Abstract: 250 words maximum, unstructured abstract.
  • Introduction:
  • Body text:
  • Acknowledgments:
  • Author contributions:
  • Conflicts of interest:
  • Financial support:
  • References: use the reference style of AMA Citaxion Style.

Short Communication

  • A short communication sent to MGR publisher about issues of concern from its readers.
  • Word limit: 500-1,000 words maximum, excluding references. No abstract, tables and figures, 1 published page.
  • Title: 90 characters (20 words) maximum.
  • Body text:
  • References: 5 maximum; use the reference style of AMA Citaxion Style.

Case Report

  • A case report sent to MGR publisher about issues of concern from its readers.
  • Word limit: 500-1,000 words maximum, excluding references. 
  • Title: 90 characters (20 words) maximum.
  • Body text:
  • References: 20-30; use the reference style of AMA Citaxion Style.


  • A commentary report sent to MGR publisher about issues of concern from its readers.
  • Word limit: 500-1,000 words maximum, excluding references. No abstract, tables and figures, 1 published page.
  • Title: 90 characters (20 words) maximum.
  • Body text:
  • References: 5 maximum; use the reference style of AMA Citaxion Style.

Letters to the Editor

  • A letter sent to MGR publisher about issues of concern from its readers.
  • Word limit: 500-1,000 words maximum, excluding references. No abstract, tables and figures, 1 published page.
  • Title: 90 characters (20 words) maximum.
  • Body text:
  • References: 5 maximum; use the reference style of AMA Citaxion Style.

Preparation of Research Articles

Manuscripts must be submitted in Word format. All components of the manuscript should be typed, double-spaced, in Arial or Times New Roman font (11 pt). All pages should be numbered consecutively beginning with the title page, followed by the graphical abstract, abstract, introduction, materials/ subjects and methods, results, discussion, references, individual tables/figures and figure legends.


  • Redundant or duplicate publication 

We ask you to confirm that your paper is original, has not been published in its current form or a substantially similar form (in print or electronically, including on a web site), that it has not been accepted for publication elsewhere, and that it is not under consideration by another publication. The ICMJE has provided details of what is and what is not duplicate or redundant publication. If you are in doubt (particularly in the case of material that you have posted on a web site), we ask you to proceed with your submission but to include a copy of the relevant previously published work or work under consideration by other journals. Authors must draw attention to any published work that concerns the same patients or subjects as the present paper in a covering letter with their article.


  • Permissions to reproduce previously published material 

MGR requires you to send us copies of permission to reproduce material (such as illustrations) from the copyright holder. Articles cannot be published without these permissions.


  • Patient consent forms 

The protection of a patient's right to privacy is essential. Please collect and keep copies of patients' consent forms on which patients or other subjects of your experiments clearly grant permission for the publication of photographs or other material that might identify them. If the consent form for your research did not specifically include this, please obtain it or remove the identifying material. 

A statement to the effect that such consent had been obtained must be included in the 'Methods' section of your paper. If necessary the individual journal Editor(s) may request a copy of any consent forms.


  • Ethics committee approval 

All articles dealing with original human or animal data must include a statement on ethics approval at the beginning of the Methods section. This paragraph must contain the following information: the name and address of the ethics committee responsible; the protocol number that was attributed by this ethics committee; the name of the Chairperson of the ethics committee (or the person who approved the protocol) and the date of approval by the ethics committee.


Title Page

Complete title

  • Should be brief (less than 20 words, 90 characters maximum), novel and informative.
  • Should attract the reader's attention.

Running title

  • Should accurately reflect the main points of the paper.
  • 40 characters maximum.
  • Should facilitate retrieval.


  • Full name of the first author and his/her afiliations (including department, institution, city with postal code and state/country, telephone number and fax number).
  • For corresponding author, please list name, highest academic degree earned, professional titles, detailed correspondence address, telephone number, fax number and e-mail address.
  • Indicate author contributions, grants, acknowledgments and conflicts of interest.
  • Declaration of patient consent: The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Abstract Page

Graphical abstract: Submission of a graphical abstract is mandatory for research articles. A graphical abstract is a single-panel figure that provides a visual summary of the main message of the article. Either a concluding or key figure from the article or a graphic specifically designed to clearly represent the main conclusions of the article should be submitted to assist readers in rapidly identifying papers relevant to their interests.

  • Image size: a minimum of 531 × 1,328 pixels (height × width); image width within the full-text width (18 cm); resolution ≥ 300 dpi.
  • File type: JPG, TIFF, PDF, or MS Office files are preferred.
  • Font: Arial or Times New Roman.

Please see examples at http://www.elsevier. com/graphicalabstracts.

Abstract: 250 words maximum, unstructured abstract. Briefly present the background of this study and the existing controversy; explain the objective, hypothesis and innovation of the study; state the problem being investigated; list the main experimental data that supports your hypothesis; and conclude by stating the relevance of the findings for the field of neural regeneration.

Key words: At least 10 key words, not present in the title, to facilitate the indexing of your paper.

Main Text



  • Present the nature and scope of the problem being investigated.
  • Review briefly the pertinent literature.
  • Provide an innovative context for the study in relation to previous work.
  • State the hypothesis and the objectives of the paper.
  • 1,000 words maximum.

Materials/Subjects and Methods


General information regarding the experimental animals or subjects involved. Indicate that the work has been approved by the appropriate ethical committees related to the institution(s) and that the experimental animals used are cared in accordance with institution guidelines.


Describe the main experimental procedures and methods that would allow readers to replicate your work; cite appropriately; provide the location (city, state (for US suppliers), and country) of the manufacturers or suppliers of the materials and equipment used.



  • Objectively and accurately describe the major findings from each experiment, and try to minimize shortcomings that will draw attention from the peer reviewers.
  • Describe the findings, from major to minor. -Use illustrations (e.g., graphs, drawing or photographs) where appropriate. Graphs and drawings should be self-explanatory.


  • Word limit: 1,000 words maximum.
  • Discuss the major novel findings of the study and describe the different characteristics from other studies.
  • Explain and extrapolate the major findings of the study; state whether the findings sup-port some viewpoint or not; purpose the new problems or concerns.
  • Discuss the significance of the major findings and how they advance the knowledge in the field of neural regeneration.
  • Provide a conclusion that clearly indicates how the results met the objectives. Do not offer a conclusion that is not supported by sufficient data.
  • Disclose the limitations and bias to embody the authenticity of the contents.
  • Make suggestions for the future direction of research that builds on your findings.
  • Indicate the theoretical significance and practical application value of the present results and make a strong conclusion.

Research articles should have a minimum of 50 references and over 30% of cited references should have been published within the preceding 3 years.

MGR uses the reference style of AMA Citaxion Style.

Figures and Tables

  • All illustrations (e.g., graphs, drawings and photographs) are considered to be figures. Each figure should be provided with a fully descriptive title and legend. The area(s) of interest must be clearly indicated with arrows or other symbols. Figure legends must be self-explanatory, which should provide sufficient detail to be intelligible without reference to the main text. All micrographs should contain a magnification scale bar. Please position the scale bar in the lower right corner of one micrograph or of the last panel (for multiple panels). The length of the scale bar should be indicated on the images or in the figure legend. The images contained in a figure are arranged in the sequence from top left to bottom right. Tags (A, B, C…) are posi-tioned in the upper left corner of each image. All abbreviations and labels appearing on the image should be explained in figure legends. If figures have been reproduced from another source, written permission for reproducing the material must be attached to the covering letter. Figures should be cited consecutively in the text and number them in that order. Each figure should be placed on a separate sheet after the reference list, including the figure title and legend. The figure title should be not lettered onto the figure itself. All measurements in the figure are in SI (metric) units. Acomma should be used to separate thousands. Labels including “*, **, ***, #, ##, ### (in that order)" are used to identify the statistical difference between datasets in the histograms or line drawings.
  • Color figure: resolution: > 300 dpi; file format PNG, EPS, TIFF, or PDF; CMYK mode should be used rather than RGB; use of high contrasting colors for color discrimination.
  • Line figures: resolution > 1,200 dpi; line width between 0.5 and 1 point; file format EPS, PDF or TIFF.
  • Grayscale figures: resolution > 600 dpi; file format EPS, TIFF or PDF. Figures should remain clear at 300-fold magnification. Figures should be sized to fit within the column (9 cm) or the full-text width (18 cm). All labels on the figure should be typed in Arial or Times New Roman font and be clearly legible.

Reporting Guidance

Manuscripts should be prepared in accordance with ICMJE Recommendation for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals. The following guidelines should be followed when writing an article:

  • ARRIVE guideline (Animal Research: Reporting of In Vivo Experiments): The ARRIVE guidelines are recommended for in vivoexperiments in animals. See for more information.
  • CONSORT statement (Consolidated Standards of Reporting Trials): The CONSORT statement is recommended for reporting randomized controlled trials. The authors are encouraged to complete 25-item checklist in their cover letter. In addition, the registration identification number and protocol version of the randomized controlled trial is listed at the end of the Abstract. See for more information.
  • STARD statement (STAndards for the Reporting of Diagnostic accuracy studies): This checklist is recommended for reporting diagnostic accuracy studies. See for more information.
  • STREGA statement (STrengthening the REporting of Genetic Associations): These guidelines are recommended for the reporting of genetic association studies. See for more information.
  • STROBE statement (STrengthening the Reporting of OBservational studies in Epidemiology): These guidelines are recommended for the reporting of observational studies in epidemiology). See for more information.
  • TREND statement (Transparent Reporting of Evaluations with Nonrandomized Designs): These guidelines are recommended for the reporting of non-randomized evaluations of behavioral and public health interventions. See for more information.
  • MOOSE checklist (a Reporting Checklist for Authors, Editors, and Reviewers of Meta-analyses of Observational Studies):This checklist is recommended for meta-analyses of observational studies. See for more information.
  • PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses): The PRISMA Statement is recommended for the reporting of systematic evaluation and meta-analysis articles. See for more information.
  • Equator Network (standards for Enhancing the QUAlity and Transparency Of health Research): This organization works to improve the reliability and value of reports on medical research studies by promoting transparent and accurate reporting of research studies. See for more information.

Conflicts of Interest/Competing Interests

When authors submit a manuscript of any type or format they are responsible for disclosing all financial and personal relationships that might bias or be seen to bias their work.

Financial relationships (such as employment, consultancies, stock ownership or options, honoraria, patents, and paid expert testimony) are the most easily identifiable conflicts of interest and the most likely to undermine the credibility of the journal, the authors, and of science itself. However, conflicts can occur for other reasons, such as personal relationships or rivalries, academic competition, and intellectual beliefs. Authors should avoid entering into agreements with study sponsors, both for[1]profit and non-profit, that interfere with authors' access to all of the study's data or that interfere with their ability to analyze and interpret the data and to prepare and publish manuscripts independently when and where they choose.

Peer reviewers

Reviewers must disclose to editors any conflicts of interest that could bias their opinions of the manuscript, and should recuse themselves from reviewing specific manuscripts if the potential for bias exists. Reviewers must not use knowledge of the work they are reviewing before its publication to further their own interests.

Editors and journal staff
Editors who make final decisions about manuscripts should recuse themselves from editorial decisions if they have conflicts of interest or relationships that pose potential conflicts related to articles under consideration. Other editorial staff members who participate in editorial decisions must provide editors with a current description of their financial interests or other conflicts (as they might relate to editorial judgments) and recuse themselves from any decisions in which a conflict of interest exists. Editorial staff must not use information gained through working with manuscripts for private gain. Editors should publish regular disclosure statements about potential conflicts of interests related to the commitments of journal staff. Guest editors should follow these same procedures.


For more information, please see author instruction at