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Serum Thyroglobulin Adds No Additional Value to Ultrasonographic Features in a Thyroid Malignancy

Youn, Inyoung MD*; Sung, Ji Min PhD; Kim, Eun-Kyung MD, PhD; Kwak, Jin Young MD, PhD

doi: 10.1097/RUQ.0000000000000056
Original Research

Abstract: We investigated the adjunctive role of preoperative serum thyroglobulin (Tg) in the diagnosis of thyroid nodules. A retrospective study was performed on 374 thyroid nodules (363 benign and 11 malignant) in 360 patients (296 women and 64 men; mean age, 50.1 years; range, 16-86 years) between December 2010 and July 2011. We evaluated clinicopathologic characteristics of patients and ultrasonographic (US) features of the lesions including presurgical Tg levels. Univariate and multivariate analysis were used to determine independent predictors of malignancy. Serum Tg was positively correlated with nodule size and thyroid volume (P < 0.001). There was no difference in serum Tg levels between malignant and benign nodules. Suspicious US features of thyroid nodules were the only independent predictors of malignancy (P< 0.001). Preoperative serum Tg was not useful in differentiating thyroid cancer from benign nodules. Suspicious US features were the only predicting factors for malignancy.

*Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea; †Graduate School of Health and Welfare, CHA University, Seongnam, South Korea; and ‡Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Received for publication September 5, 2013; accepted October 22, 2013.

The authors declare no conflict of interest.

Reprints: Jin Young Kwak, MD, PhD, Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea (e-mail: docjin@yuhs.ac).

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