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Comparison of 2 Oral Ultrasonography Contrast Agents: Simethicone-Coated Cellulose and Simethicone-Water Rotation in Improving Pancreatic Visualization

Ishigami, Kousei MD; Abu-Yousef, Dina M. MD; Kao, Simon C.S. MD; Abu-Yousef, Monzer M. MD

doi: 10.1097/RUQ.0000000000000052
Original Research

Purpose: The purpose of this study was to prospectively compare the efficacy of 2 oral ultrasonography (US) contrast agents (simethicone-water rotation [SWR] and simethicone-coated cellulose [SCC]) in improving visualization of the pancreas.

Methods: Two sessions (SWR and SCC) of transabdominal US studies were performed on 38 healthy volunteers. In each session, US images were obtained in precontrast supine and upright positions and postcontrast supine and upright positions. The visualization of the pancreas was graded on a scale of 1 to 5 (1 = nonvisualization, 5 = excellent visualization), grading the head, body, and tail separately.

Results: In the supine position, SWR significantly improved the visualization of the pancreatic head, body, and tail, whereas there were no significant differences between SCC and precontrast images. Simethicone-water rotation showed significantly better visualization than SCC. The average scores of the head, body, and tail of the pancreas that graded 4 or more were 15.8% of precontrast, 21.1% of SCC, and 50% of SWR. In the upright position, both SWR and SCC significantly improved the visualization of the pancreas, except for the pancreatic body on SCC. There were no significant differences between SWR and SCC. The average scores that graded 4 or more were 26.3% of precontrast, 57.9% of SCC, and 65.8% of SWR.

Conclusion: Simethicone-water rotation was more effective than SCC in improving the visualization of the pancreas.

Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA.

Received for publication July 10, 2013; accepted October 2, 2013.

The authors declare no conflict of interest.

Reprints: Kousei Ishigami, MD, Department of Radiology, University of Iowa Hospitals and Clinics, 3885 JPP, 200 Hawkins Dr, Iowa City, IA 52242 (e-mail: kousei-ishigami@uiowa.edu).

© 2014 by Lippincott Williams & Wilkins