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Kidney Fibrosis: Origins and Interventions

Vanhove, Thomas MD; Goldschmeding, Roel MD, PhD; Kuypers, Dirk MD, PhD

doi: 10.1097/TP.0000000000001608
Reviews

All causes of renal allograft injury, when severe and/or sustained, can result in chronic histological damage of which interstitial fibrosis and tubular atrophy are dominant features. Unless a specific disease process can be identified, what drives interstitial fibrosis and tubular atrophy progression in individual patients is often unclear. In general, clinicopathological factors known to predict and drive allograft fibrosis include graft quality, inflammation (whether “nonspecific” or related to a specific diagnosis), infections, such as polyomavirus-associated nephropathy, calcineurin inhibitors (CNI), and genetic factors. The incidence and severity of chronic histological damage have decreased substantially over the last 3 decades, but it is difficult to disentangle what effects individual innovations (eg, better matching and preservation techniques, lower CNI dosing, BK viremia screening) may have had. There is little evidence that CNI-sparing/minimization strategies, steroid minimization or renin-angiotensin-aldosterone system blockade result in better preservation of intermediate-term histology. Treatment of subclinical rejections has only proven beneficial to histological and functional outcome in studies in which the rate of subclinical rejection in the first 3 months was greater than 10% to 15%. Potential novel antifibrotic strategies include antagonists of transforming growth factor-β, connective tissue growth factor, several tyrosine kinase ligands (epidermal growth factor, platelet-derived growth factor, vascular endothelial growth factor), endothelin and inhibitors of chemotaxis. Although many of these drugs are mainly being developed and marketed for oncological indications and diseases, such as idiopathic pulmonary fibrosis, a number may hold promise in the treatment of diabetic nephropathy, which could eventually lead to applications in renal transplantation.

Although the cause of fibrosis in renal allografts is nonspecific, fibrosis is a dominant feature of severe acute or chronic injury with poor prognostic implications and current strategies to prevent or control fibrosis are lacking and thus requiring novel therapeutic strategies.

1 Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven, Belgium.

2 Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.

3 Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.

Received 20 September 2016. Revision received 24 October 2016.

Accepted 10 November 2016.

The authors declare no funding or conflicts of interest.

T.V. wrote the article. R.G. and D.K. reviewed the article.

Correspondence: Dirk R J Kuypers, MD, PhD, Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. (dirk.kuypers@uzleuven.be).

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