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Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling

Benke, Kálmán MD; Sayour, Alex Ali MS; Mátyás, Csaba MD; Ágg, Bence MD; Németh, Balázs Tamás MD; Oláh, Attila MD, PhD; Ruppert, Mihály MD; Hartyánszky, István MD, PhD; Szabolcs, Zoltán MD, PhD; Radovits, Tamás MD, PhD; Merkely, Béla MD, PhD; Szabó, Gábor MD, PhD

doi: 10.1097/TP.0000000000001585
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Abstract: Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the experimental studies on rat heart transplantation to illustrate changes that occur to the myocardium due to volume unloading. We divided the literature based on whether normal or failing rat heart models were used. This analysis may provide a basis to understand the physiological effects of mechanical circulatory support therapy.

To understand the effects of mechanical unloading, the authors summarize the findings of volume-dependent myocardial remodelling in the latest experimental studies on rat heart transplantation models.

1 Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

2 Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.

Received 10 July 2016. Revision received 25 October 2016.

Accepted 26 October 2016.

Kálmán Benke, Alex Ali Sayour, Béla Merkely, and Gábor Szabó contributed equally to this study.

The authors declare no funding or conflicts of interest.

Correspondence: Kálmán Benke MD, Semmelweis University, Heart and Vascular Center, Budapest, Hungary H-1122 Budapest, Varosmajor str. 68. (kalman.benke@gmail.com).

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