Transplantation

Skip Navigation LinksHome > March 15, 2014 - Volume 97 - Issue 5 > Extended Spectrum β-Lactamase–Producing Enterobacteriaceae I...
Transplantation:
doi: 10.1097/01.TP.0000436928.15650.59
Clinical and Translational Research

Extended Spectrum β-Lactamase–Producing Enterobacteriaceae Infection in Heart and Lung Transplant Recipients and in Mechanical Circulatory Support Recipients

Bui, Kevin T.1; Mehta, Seema1; Khuu, Tam H.2; Ross, David3; Carlson, Margrit1; Leibowitz, Matthew R.1; Schaenman, Joanna M.1; Saggar, Rajan3; Lynch, Joseph P. III3; Ardehali, Abbas4; Kubak, Bernard M.1,5

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Abstract

Background: Extended spectrum β-lactamase (ESBL)–producing gram-negative bacilli are increasingly reported in patients with a variety of risk factors including prior cephalosporin and antibiotic usage, prolonged hospitalizations, existence of comorbid conditions, and critical illness.

Methods: Retrospective review of infections caused by ESBL-producing Enterobacteriaceae was performed in heart transplant (HTx), lung transplant (LTx), and mechanical circulatory support (MCS) device recipients at a large transplant center.

Results: Among 1065 patients transplanted/implanted, the incidence of ESBL-related infections (bacteremia, urinary tract infections, pneumonia, central venous catheter–associated infection, and wound infections) in HTx, LTx, and MCS device recipients was reported at 2.2%, 5.5%, and 10.7%, respectively, caused by ESBL-producing Klebsiella pneumoniae, Escherichia coli, Klebsiella oxytoca, and Citrobacter freundii.

Conclusions: Early detection and adequate duration of therapy for ESBL-producing Enterobacteriaceae in solid organ transplants and MCS device recipients are essential in successful patient outcomes including prevention of recurrent infection.

© 2014 by Lippincott Williams & Wilkins

 



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