Skip Navigation LinksHome > January 27, 2012 - Volume 93 - Issue 2 > Further Evidence for Amyloid Deposition in Clinical Pancreat...
Transplantation:
doi: 10.1097/TP.0b013e31823e46ef
Clinical and Translational Research

Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

Westermark, Gunilla T.1,8; Davalli, Alberto M.2; Secchi, Antonio2; Folli, Franco3; Kin, Tatsuya4; Toso, Christian4,5; Shapiro, A. M. James4; Korsgren, Olle6; Tufveson, Gunnar7; Andersson, Arne1; Westermark, Per6

Collapse Box

Abstract

Background. The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells.

Materials and Methods. Sections from liver material from four deceased islet-bearing recipients have been scrutinized for the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have been published previously.

Result. With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplanted into the liver in three of four patients with type 1 diabetes.

Conclusion. The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be an important cause of progressing β-cell dysfunction in clinically transplanted islets.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.