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USE OF MYCOPHENOLATE MOFETIL AS RESCUE THERAPY AFTER PEDIATRIC LIVER TRANSPLANTATION

Chardot, C.1; Nicoluzzi, J. E.; Janssen, M.; Sokal, E.; Lerut, J.; Otte, J. B.; Reding, R.

Transplantation:
Clinical Transplantation
Abstract

Background. Mycophenolate mofetil (MMF) has been increasingly used after liver transplantation (LT) in adults. We report our preliminary experience with MMF as rescue therapy after pediatric LT.

Methods. A total of 19 children received MMF for 21 indications. Median age at LT was 30 months (range 7–149). The median initial oral dose of MMF was 23 mg/kg/day (range 12–43) orally. Median follow-up after initiation of MMF therapy was 642 days (range 229–1606).

Results. 1) Efficacy: MMF was indicated for rejection or insufficient immunosuppression in 16 cases, with normalization of both liver function tests and liver histology in 10 (62%). MMF was successfully used in one patient with post-LT immmune hepatitis and one patient with corticodependence. In three patients with renal function impairment, MMF allowed reduction of cyclosporine A or tacrolimus blood levels, without subsequent rejection. 2) Tolerance: Six patients (32%) experienced eight side effects, mainly gastrointestinal and hematological, which resolved after cessation of MMF in five cases and dose reduction in three. One case of posttransplant lymphoproliferative disease (PTLD) occurred under MMF therapy (5.2%). Four patients had EBV primary infection, while under MMF therapy, without subsequent PTLD. Three patients had CMV primary infection, and five CMV reactivation, under MMF therapy. Seven remained asymptomatic, and one presented with CMV enteritis.

Conclusions. These preliminary results suggest that MMF is an effective and safe immunosuppressant in pediatric LT recipients. Its use is hampered by frequent gastrointestinal and hematological side-effects. MMF does not seem to increase the risk of PTLD nor CMV disease.

Author Information

Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Avenue Hippocrate 10, B-1200 Brussels, Belgium

1 Address correspondence to: Christophe Chardot, MD, PhD, Centre hospitalier universitaire de Bicêtre, Service de chirurgie pédiatrique, 78 rue du général Leclerc, F-94275 LE Kremlin-Bicetre, France.

Received 30 March 2000.

Accepted 25 May 2000.

© 2001 Lippincott Williams & Wilkins, Inc.