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Cellular Imaging With MRI

Makela, Ashley V. BSc; Murrell, Donna H. BSc; Parkins, Katie M. BSc; Kara, Jenna BSc; Gaudet, Jeffrey M. BSc; Foster, Paula J. PhD

Topics in Magnetic Resonance Imaging: October 2016 - Volume 25 - Issue 5 - p 177–186
doi: 10.1097/RMR.0000000000000101
Review Articles

Cellular magnetic resonance imaging (MRI) is an evolving field of imaging with strong translational and research potential. The ability to detect, track, and quantify cells in vivo and over time allows for studying cellular events related to disease processes and may be used as a biomarker for decisions about treatments and for monitoring responses to treatments. In this review, we discuss methods for labeling cells, various applications for cellular MRI, the existing limitations, strategies to address these shortcomings, and clinical cellular MRI.

*Imaging Research Laboratories, Robarts Research Institute

Department of Medical Biophysics, Western University, London, Ontario, Canada.

Address correspondence to Paula J. Foster, PhD, Robarts Research Institute, 1151 Richmond St N, London, ON N6A 5B7, Canada. (e-mail: pfoster@robarts.ca).

Ashley V. Makela and Donna H. Murrell are co-first authors.

The authors report no conflicts of interest.

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.