Successful health promotion and disease prevention efforts require not only the development of evidence-based programs but also the broad dissemination of those programs. In this article, we trace the development and dissemination of an evidence-based exercise program for older adults, EnhanceFitness (EF). We summarize its effectiveness, describe its adoption by partners, and highlight best practices related to program maintenance. We organize the article around a program planning and evaluation framework called RE-AIM. The EF enterprise remains robust because of its scientific evidence (it works), easy replicability, low-cost, strong advocates, timely technical assistance, and affiliation with an academic partner.