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Topics in Clinical Nutrition:
doi: 10.1097/TIN.0b013e31826f8e02
Clinical Questions and Reviews

Case Study: Efficacy of Orlistat 60 mg Treatment for Weight Loss

Smith, Tracey J. PhD, RD; Walker, Leila MS; Cummins, Deborah PhD; Crombie, Aaron PhD, RD; Funderburk, LesLee PhD, RD; Young, Andrew J. PhD; Touger-Decker, Riva PhD, RD

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Individuals who are overweight or obese are at risk for multiple comorbidities (eg, hypertension, dyslipidemia, type 2 diabetes, coronary artery disease). Pharmacotherapy combined with lifestyle modification, energy restriction, and increased physical activity has been suggested as a potential treatment option for overweight or obese individuals. Orlistat, one pharmacological treatment option, inhibits pancreatic and gastric lipase activity. It is available both as a prescription drug (120 mg taken 3 times per day with meals) and as an over-the-counter drug (60 mg taken 3 times per day with meals). The efficacy of orlistat 60 mg for weight loss in overweight and obese individuals is addressed in this article. A case study is also presented, which explores orlistat 60 mg use in a 31-year-old obese man, with emphasis on efficacy, compliance, and adverse effects.

© 2012 Lippincott Williams & Wilkins, Inc.


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