The objectives of this article were to determine whether post-pyloric administration of enteral formula influenced the attainment of nutritional goals and length of hospitalization compared to gastric enteral feeding. Data were collected retrospectively from the medical charts of gastrically (n=63) and post-pylorically (n=23) fed enteral, intensive care patients. No significant differences in patient or enteral formula characteristics were observed. Significantly more gastrically fed patients had gastric residual volumes which warranted feeding cessation (P<0.031). A higher percentage of the post-pylorically fed patients reached their nutritional goals compared to the gastrically fed patients (P<0.0001) and their length of hospitalization was diminished (P<0.001).