INSTRUCTIONS What nurse practitioners should know about gene therapy
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What nurse practitioners should know about gene therapy
General Purpose: To provide information about the progress of gene therapy clinical trials toward the management of patients with chronic disease. Learning Objectives: After reading this article and taking this test, you will be able to: 1. Recognize the progress that has been made in gene transfer therapy. 2. Identify elements of concern when gene therapy is applied to human patients.
- The focus of gene therapy is to
- sequence human genomes.
- identify gene function and expression.
- define nongenetic and genetic factor interactions.
- treat disease through the use of genes.
- Compared to viral gene therapy, nonviral gene therapy is associated with
- secondary disease.
- fatal immunologic responses.
- increased adverse reactions.
- increased safety profile.
- Unlike germline human therapy, somatic gene therapy
- alters precursor cells.
- causes noninheritable effects.
- alters the DNA in sperm.
- is extremely controversial.
- Which of these is a type of somatic gene therapy?
- Trials using human factor IX transgene resulted in
- maximum adverse reactions.
- decreased bleeding.
- increased platelet production.
- resurgence of hemophilia B.
- A recent animal study using silencing RNA therapy demonstrated
- reduction of ovarian tumor proliferation.
- tumor growth association with claudin 3.
- decreased factor IX for patients with hemophilia B.
- exacerbation of Bcl-2 proliferation in neuroblastoma tumors.
- Which type of encoded protein is used in suicide gene therapy?
- diphtheria toxin
- nucleic acid
- Which of these serves as a delivery vector for corrective gene therapy?
- Which virus is often used for gene delivery because it invades the nuclei of cells without permanent alteration of the host genome?
- anopheles B virus
- Use of which of these vectors has improved the outcomes of nonviral therapy strategies?
- Adenoviruses have been shown to
- target and infect cells.
- increase the chance of disruption of normal gene function.
- decrease recipient safety.
- deliver DNA that integrates into the host DNA.
- Lentivirus is being studied as a vector for the treatment of diseases of the
- Which of the following is not considered a potential danger of viral gene therapy?
- undesired tissue mutations
- infection of nontargeted organs
- onset of systemic toxicities
- dermal transfer to other subjects
- Lipoplexes are administered
- Lipoplexes commonly accumulate in the
- adipose tissue.
- In a trial that evaluated the effects of naked DNA to deliver hepatocyte growth factor to ischemic limbs, results included
- decreased ankle-brachial index.
- decreased angiogenesis.
- increased wound healing.
- increased limb pain.
- Which of the following is used in conjunction with siRNA administration for more efficacious gene silencing?
- photochemical internalization
- naked DNA
- Which of these produced a greater immunoprotective response when used as an intradermal delivery method of DNA and RNA?
- jet injector
- gene gun
- dermal patch
- hydrophyllic membrane