U-500 concentrated regular insulin: Practical application in the outpatient settingTaylor, Sarah CNP, MSN, CDENurse Practitioner: 10 September 2012 - Volume 37 - Issue 9 - p 47–52 doi: 10.1097/01.NPR.0000418384.83735.7c Feature: DIABETES CARE Abstract Author Information Abstract: Administering large insulin doses to patients with severely insulin-resistant diabetes is often ineffective, expensive, and painful. U-500 regular insulin is absorbed better, less painful, and more cost-effective due to the reduced volume. This article describes the most recent guidelines for U-500 insulin in the clinical setting. Sarah Taylor is a clinical nurse practitioner at The Ohio State University Medical Center, Division of Endocrinology, Diabetes, and Metabolism. The author has disclosed no financial relationships related to this article. © 2012 Lippincott Williams & Wilkins, Inc.