Fever of unknown origin: An evidence-based approachHolder, (Bonnie) M.A. PhD, APRN, BC; Ledbetter, Carol PhD, APRN, BC, FAANNurse Practitioner: August 2011 - Volume 36 - Issue 8 - p 46–52 doi: 10.1097/01.NPR.0000399714.32080.49 Feature: PRIMARY CARE Abstract Author Information Abstract: This article reviews the classification and etiology of fever of unknown origin (FUO) in the adult population. A systematic diagnostic approach is discussed, equipping the NP to follow a careful history and physical, as well as focused diagnostic tests and procedures to determine the underlying cause of FUO. M.A. (Bonnie) Holder is currently an Assistant Professor at the University of North Florida. Carol Ledbetter is the director of the Doctor of Nursing Practice Program at the University of North Florida, Brooks College of Health School of Nursing. The authors have disclosed they have no financial relationship related to this article. © 2011 Lippincott Williams & Wilkins, Inc.