Journal of Thoracic Imaging:
Positron Emission Tomography/Magnetic Resonance Imaging Evaluation of Lung Cancer: Current Status and Future Prospects
Yoon, Soon Ho MD*,†; Goo, Jin Mo MD, PhD*,†,‡; Lee, Sang Min MD*,†; Park, Chang Min MD, PhD*,†,‡; Seo, Hyo Jung MD§; Cheon, Gi Jeong MD, PhD‡,§
Departments of *Radiology
‡Cancer Research Institute, Seoul National University College of Medicine
†Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
Supported in part by a grant from Guerbet Korea.
The authors declare no conflicts of interest.
Reprints: Jin Mo Goo, MD, PhD, Department of Radiology, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea (e-mail: email@example.com).
Various designs of positron emission tomography/magnetic resonance imaging (PET/MRI) systems have been recently introduced to clinical practice, which have overcome preexisting technical challenges concerning the fusion of PET and MRI systems. Although further improvements are still necessary especially for bony lesions, quantification using current MRI-based attenuation correction techniques has been shown to be comparable to that of PET/computed tomography (CT) systems. On the basis of the results of previous whole-body MRI studies, PET/MRI is expected to show even better performance than PET/CT in M-staging especially for brain and liver metastases. Another advantage of PET/MRI over PET/CT, in addition to good soft tissue contrast, is the potential reduction in radiation dose. The next important hurdle to overcome for its clinical application is the development of time-efficient protocols for lung cancer evaluation and interpretation of discordant results from both modalities. Multiparametric imaging through PET/MRI will help radiologists better understand tumor biology and better evaluate treatment response.
In addition to improvements in imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI), advances in combined multimodality imaging technologies such as positron emission tomography (PET)/CT have improved clinical patient care especially in oncologic imaging. Since their introduction in 2000,1 PET/CT scanners have become widely implemented and have enormously contributed to the diagnosis, treatment, and prediction of prognosis in oncologic patients.2 Thereafter, a number of studies including a randomized controlled trial on the use of PET/CT for preoperative staging of non–small cell lung cancers have proven the superior efficacy of PET/CT in cancer staging over conventional staging methods.3–6 At present, PET/CT has become a standard imaging modality in lung cancer staging, and its cost-effectiveness has been validated.7
Despite the many advantages of MRI, including excellent soft tissue contrast resolution and absence of radiation exposure, it has been an underutilized imaging modality for evaluating thoracic diseases, as considerable challenges in MRI acquisition for the lung still exist because of low proton density, inhomogeneity of the magnetic file in the lung, and cardiac and respiratory motion artifacts.8 With recent technical advances such as fast imaging and parallel imaging techniques in MRI, previous limitations have been partially overcome. In addition, new methods using either a moving-table platform in combination with the body coil or a specially designed rolling-table platform with 1 body phased-array coil have made it feasible to perform whole-body MRI for lung cancer staging.9–11 Considering the success of PET/CT in oncology practice and the innate limitations of PET/CT in terms of soft tissue contrast resolution and radiation exposure, a fusion of PET and MRI has garnered much attention as it is a conjunction of molecular information offered by PET and anatomic/potentially functional information with high contrast and spatial resolution provided by MRI.12 We can anticipate the potential strengths and limitations of PET/MRI as this modality has components of both PET and MRI.
The various kinds of radioisotopes used in PET can depict several important biological properties including glucose metabolism, tissue hypoxia, perfusion, and apoptosis; and MRI can yield images reflecting cellular density, perfusion, hypoxia, and metabolic features in tissue in addition to basic T1-weighted and T2-weighted MRI images offering high-resolution anatomic information with different contrasts according to the evolution of several MRI sequences. In addition to these potential advantages, PET/MRI also has an important advantage over PET/CT in terms of radiation dose. Although the underlying technical obstacles have not yet been fully resolved, various designs of PET/MRI systems including fully integrated hybrid scanners have been recently implemented in clinical practice. In this review, we discuss the instrumentation, technical aspects, results of studies obtained with PET/CT and whole-body MRI, recent results with integrated PET/MRI, and potential applications related to PET/MRI in lung cancer.
HARDWARE DESIGN OF PET/MRI SYSTEMS
An ideal combination of PET and MRI is a hybrid system in which PET and MRI signals can be acquired simultaneously. However, the integration of PET and MRI systems within a single gantry has innate technical difficulties, as the signal acquisition process of the 2 modalities is completely different causing interference between the 2 systems.13 Indeed, PET detectors can be interfered with by the strong B0 static magnetic field, abrupt changes in the B1 gradient magnetic field, and radiofrequency pulse during the signal acquisition of an MRI system. Conversely, MRI detectors can also be affected by electromagnetic radiation from PET electronics, magnetic field inhomogeneity derived from PET devices, and eddy currents. Unless these interferences can be resolved, the simultaneous acquisition of PET and MRI images will result in significant degradation of image quality.
There are 2 major strategies in the design of a PET/MRI system adopted by vendors (Fig. 1). One is the tandem arrangement, and the other is the concurrent arrangement of PET and MRI scanners. The tandem arrangement enables sequential acquisition of PET and MRI signals without major modification to PET and MRI scanners, which are located to avoid mutual interference either in the same space or in 2 separate spaces. Ingenuity TF (Philips Healthcare, Best, Netherlands) operates PET and MRI scanners with back-to-back configurations in the same room. In the case of the Discovery PET/CT and MRI system (GE Healthcare, Milwaukee, WI), PET/CT and MRI scanners are combined and sequentially performed in 2 separate rooms. Compared with the concurrent type of arrangement, PET/MRI systems with tandem arrangement have demerits not only in the potential anatomic mismatch, which may occur due to patient motion, but also in temporal mismatch, which may occur due to the sequential acquisitions of PET and MRI images.
Biograph mMR (Siemens Healthcare, Erlangen, Germany) adopted a fully integrated PET/MRI system using the concurrent configuration. One of the biggest technical difficulties in the integration of PET/MRI systems is related to the photosensor of the PET detector, as the photomultiplier tube traditionally used in PET or PET/CT systems is very sensitive to the magnetic field. An introduction of avalanche photodiodes, which are insensitive to magnetic fields, has enabled the development of hybrid PET/MRI scanners such as Biograph mMR, although avalanche photodiodes are inferior to photomultiplier tubes in terms of gain and temporal resolution. The implementation of silicon photodiodes (Geiger-mode avalanche photodiodes) in hybrid PET/MRI scanners is currently underway as silicon photodiodes have higher gain and faster temporal resolution enabling time-of-flight PET in addition to the advantages of avalanche photodiodes.14 With the technical evolution regarding PET, MRI scanners, and RF shielding, simultaneous acquisition of PET and MRI signals is now possible without significant interference in Biograph mMR hybrid scanners.15 Simultaneous acquisition provides better anatomic and temporal registration of MRI and PET signals allowing more robust interpretation of disease biology.16
Software-based image registration is another option to generate PET/MRI images by fusing separately acquired PET and MRI images.17 Several computation algorithms fusing PET and MRI images have been proposed with varying degrees of success in registration.18 The trimodality system, which combines PET/CT and MRI systems located in separate rooms, has shown a weakness with regard to the radiation dose, as the CT scanner of PET/CT is used for image acquisition. Comparison of features of integrated, sequential, and coregistered PET/MRI systems is detailed in Table 1.
TECHNICAL ISSUES IN PET/MRI
MRI-based Attenuation Correction
Attenuation correction is essential for the quantification of PET data as some portion of photons emitted from radiotracers is variably absorbed across different body tissues before arrival at the PET detector. To correct the attenuation of emitted photons throughout the body, an attenuation map with information regarding the distribution of attenuation coefficients is needed. Contrary to the PET/CT system in which the CT attenuation coefficient is linear to electron density, MRI signal intensity in the PET/MRI system has no direct relationship to electron density. Several approaches deriving attenuation coefficients from MRI images have been proposed,19 and routine applications of MRI-based attenuation corrections for whole-body PET/MRI are based on the acquisition of dedicated MRI sequences such as the DIXON sequence with in-phase/opposed-phase images. The Dixon MRI sequence provides separate water and fat images and creates an attenuation map (μ map) with 4 distinct tissue classes: background, lung, fat, and soft tissue (Fig. 2). The lungs are identified by connected-component analysis of the air in the inner part of the body. In addition, difficulty in differentiating air, lung, and bone on conventional MRI sequences makes MRI-based attenuation correction more complicated in the PET/MRI system. Importantly, as bony structures are not considered by currently applied MRI-based attenuation correction methods, these structures undergo a systematic undercorrection of PET data. Maximum errors of decreased uptake in bone are up to 13% or 17% in standardized uptake value (SUV).20–22 Another option for attenuation correction in the PET/MRI system is the use of an anatomic atlas template to coregister patient data sets. Contrary to easier registration in the brain, the atlas-based method itself remained challenging for the whole body. Recently, the atlas-based method in conjunction with regional segmentation derived from the MRI sequence was reported to be technically feasible and was shown to provide better results than pure regional segmentation using the MRI sequence.23
Despite this source of error in SUV, recent studies using an integrated PET/MRI system revealed that the PET image quality was subjectively rated high and that the diagnostic value was comparable to that of standard PET/CT systems.24,25 In the clinical application of PET wherein the diagnosis is often based on qualitative evaluation, accuracy in quantification may not be crucial as far as these errors do not affect image quality (Fig. 3).26 However, PET/MRI-based therapy response assessment in oncologic disease requires accurate PET quantification, and therefore further improvement in MRI-based attenuation correction is necessary.
Precise alignment is necessary to characterize pathologic findings when combining different imaging modalities. However, bulk patient motion or various physiological motions of respiration, bowel movements, or urinary bladder filling can cause misalignment in hybrid imaging. Anatomic alignment is expected to improve with simultaneous acquisition of PET/MRI compared with retrospectively fused PET and MRI. A recent study dealt with this issue and confirmed that the alignment of hybrid data sets acquired in simultaneous whole-body PET/MRI was more accurate than retrospective fusion in abdominal organs.27 In the urinary bladder, the alignment of simultaneous PET/MRI was more accurate than PET/CT. When the effect of different breathing protocols of simultaneous, sequential, and MRI-gated data acquisition was compared, the alignment of thoracic PET/MRI with expiratory breath-hold or free-breathing MRI was more accurate than with inspiratory MRI.
Other Sources of Artifacts and Errors
In calculating SUV, other sources of attenuation, such as surface coils, and additional positioning devices must be considered. These devices can cause scattering and attenuation of the PET signal. With regard to MRI contrast agents, ingestion of an oral iron oxide–based MRI contrast agent has been shown to affect the MRI-based attenuation map even though PET quantification is not affected by intravenous injection of the MRI contrast agent.28 In addition, metallic implants can produce a signal loss resulting in underestimated uptake in the region surrounding the metallic implants, and truncation artifacts may arise from the difference in the transverse fields of view of PET and MRI (Fig. 4). To recognize attenuation-related artifacts, it is important to evaluate the non–attenuation-corrected images.
Partial volume effects are another source of potential error that can affect the quantitative accuracy of PET. SUV can be underestimated with decreasing tumor volume, and therefore it can be affected by applying different partial volume correction methods.29 Thus far, studies have shown that reconstruction-based partial volume correction, which includes 3-dimensional (3D) point spread function, outperforms image-based methods in terms of accuracy.29
To reduce motion artifacts, physiological gating such as electrocardiogram gating and MRI-based triggering of PET data can be applied. One requirement in applying these techniques is to consider the associated increase in examination time. An alternative approach to reducing respiratory motion–related errors is the MRI-based respiratory motion correction of PET that can improve tumor visibility, delineation, and maximum SUV.16
Unlike PET/CT, the design of PET/MRI protocols for whole-body coverage is more complex, and time efficiency is an especially important issue. PET/MRI can be performed in approximately 25 minutes without further morphologic MRI. However, with a number of additional diagnostic sequences and with the use of an intravenous contrast, the examination time may increase up to 90 minutes or more. With MRI sequences such as diffusion, perfusion MRI, and MRI spectroscopy, more functional and biological properties can be obtained at the cost of a longer examination time. Therefore, the numbers and types of MRI sequences required need to be specifically chosen and optimized according to the clinical tasks of PET/MRI.30 A continuous moving-table data acquisition scheme can be applied in postcontrast studies.31
IMAGE ACQUISITION WITH AN INTEGRATED PET/MRI SYSTEM
As most clinical studies on PET/MRI were carried out with the integrated PET/MRI system, this section regarding image acquisition is based on integrated PET/MRI. Most differences in designing PET/MRI scanning protocols come from the MRI protocols. Optimizing the PET/MRI protocol is an important issue, which is under active investigation. Due to time constraints, especially for whole-body imaging, priority among various MRI sequences should be considered in adding dedicated MRI for specific body parts. This issue is essentially the same for sequential PET/MRI systems except that they need more examination time to perform the same protocol. The MRI part in PET/MRI plays a role for anatomic localization, attenuation correction of PET data, and tissue characterization based on selected MRI techniques.
Before examination, in the case of administration of 18F-fluoro-2-deoxyglucose (18F-FDG), fasting, control of glucose level, and having the patient rest between 18F-FDG administration and imaging to minimize muscle uptake are required for patient preparation. In addition to preparations for stand-alone MRI, care should be taken so that only dedicated coils approved for PET/MRI are used, as the surface coils may cause additional attenuation of 511 keV photons.
PET/MRI Acquisition Protocols
As the PET/MRI scan protocol for the staging of lung cancer has not been standardized as yet, the general principles for PET/MRI scans and the specific scan protocol in our center will be introduced. The predominant factors for PET/MRI scan time are the number and type of the MRI sequence. Despite the variability of whole-body MRI scan protocols across the literature,3,9–11,32,33 a whole-body MRI scan can be performed with a combination of a coronal or axial fast T2-weighted sequence (eg, half-Fourier acquisition single-shot turbo spin-echo sequence), fast T1-weighted sequence (eg, volume-interpolated 3D-spoiled gradient-echo sequence), short-τ inversion recovery (STIR) sequence, and diffusion-weighted MRI sequence covering organs in which metastasis frequently occurs. In addition, contrast-enhanced MRI scans are essential for better detection of metastases in solid organs including the brain, liver, and leptomeninges.34–36 The initial step is obtaining MRI localizers to plan the subsequent acquisition. At each bed position, while PET imaging is acquired, the MRI sequence for attenuation correction, which takes 19 seconds per bed position, is acquired first, followed by subsequent simultaneous MRI sequences for diagnostic purposes. As the axial range of a single bed position is 25.8 cm with a 6.1 cm overlap between adjacent bed positions in the current integrated PET/MRI system, 2 to 5 bed positions are required for lung cancer staging to cover a body part or the whole body. MRI for a specific region of interest can be acquired additionally with or without simultaneous PET scanning according to diagnostic purposes. With regard to PET scan, the number of bed positions and the acquisition time for each should be determined for PET imaging, which is obtained in the step-and-shoot mode. PET acquisition time is 2 to 4 minutes per bed position, but this can be increased for simultaneous MRI acquisitions. The dedicated PET/MRI scan protocol for lung cancer preliminarily used in our center was developed for the purpose of both clinical practice and academic research (Fig. 5) and is expanded from a basic whole-body PET/MR scan protocol (Fig. 6).
FUTURE PROSPECTS ON CLINICAL APPLICATION IN LUNG CANCER
Currently, there are very few studies investigating pulmonary malignancies using an integrated PET/MRI machine. Herein, we briefly review the results of preliminary studies based on coregistration of PET and MRI or PET/MRI systems to better comprehend the potential role of integrated PET/MRI in lung cancer.
Detection and Assessment of Pulmonary Nodules
At present, CT is the standard and best imaging modality for the detection of pulmonary nodules due to its high spatial and temporal resolution. Despite improvement of MRI techniques, current MRI sequences used in PET/MRI systems are not sufficient for visualization of small lung nodules of 5 mm or less.37–40 The detection rate of MRI with various sequences has ranged between 45.5% and 96.0%, and the detection rate of spin-echo sequences was better than that of gradient-echo sequences.8,37–40 In a prospective comparative study on whole-body MRI and PET/CT, more pulmonary metastases were found on PET/CT than on MRI (170 vs. 139 pulmonary metastases).3 In addition, in a recent study that used an integrated PET/MRI system, radial volumetric interpolated breath-hold examinations and PET acquired with PET/MRI detected 70.3% of all nodules and 95.6% of FDG-avid nodules, and 88.6% of nodules 5 mm in diameter or larger were detected compared with the PET/CT system, which detected 69 nodules including 45 FDG-avid nodules.41 This weakness of PET/MRI in detecting pulmonary nodules might not be problematic on the initial workup of lung cancer staging given that chest CT is routinely performed at initial diagnosis. However, substitution of PET/CT with PET/MRI during follow-up in patients with lung cancer might only be possible in combination with chest CT until better MRI sequences are developed for detection of metastatic nodules in the lung.11,42 As PET/CT can also fail to detect small metastatic lung nodules found on chest CT,43 PET/MRI with low-dose CT may be the best option for postoperative surveillance in lung cancer patients.
FDG-PET/CT has demonstrated efficacy in differentiating malignant from benign nodules, but this has limited value in the detection of ground-glass nodules and has yielded a considerable number of false-positive results for these nodules, mainly because of inflammation.44,45 On the basis of the concept that malignant lesions demonstrate increased cellularity, high tissue disorganization, and increased extracellular space tortuosity compared with benign lesions, malignant lesions show high signal intensity on diffusion-weighted imaging (DWI) and low apparent diffusion coefficients (ADC). However, granulomas, active inflammation, or fibrous nodules may also show high signal intensity, similar to malignant nodules.8 The use of dynamic contrast-enhanced MRI demonstrated high diagnostic capability in distinguishing malignant from benign nodules, with sensitivities ranging from 94% to 100% and specificities from 70% to 96%.8
Assessment of TNM Staging
T-staging is assessed mainly on the basis of tumor size and invasion of adjacent tissue according to the seventh edition of the TNM staging system for lung cancer.46 When compared with the CT scan, the MRI scan showed higher diagnostic performance in assessing locoregional invasion to the chest wall, mediastinum, and diaphragmatic pleura, as MRI offers clear visualization of the extrapleural fat plane, pleural abnormality on T1-weighted and T2-weighted images, chest rib destruction on STIR images, and adhesion between the chest wall and mass on dynamic cine MRI images.47–50 In a study by Plathow et al,51 whole-body MRI obtained with 1.5 T MRI provided correct T-staging in all patients, whereas PET/CT did not correctly stage chest wall invasion in 4 of 52 patients. In another study by Yi et al,11 when PET/CT and whole-body MRI obtained with 3 T MRI were compared, there were no significant differences in T-staging assessment. In a recent study that included 10 patients with pathologically proven or clinically suspected lung cancers, an integrated PET/MRI system excluded the infiltration of the mediastinal pleura by the tumor suspected at PET/CT in 1 patient and led to understaging due to slightly smaller measurement of the tumor size compared with PET/CT.25
Although CT is the standard modality in lung cancer staging, the major weakness of CT is its low accuracy in N-staging because only size is considered to determine metastatic lymph nodes. In comparison, FDG-PET has shown better performance in determining metastatic lymph nodes. MRI is also superior to CT in diagnosing mediastinal lymph node metastasis, as metastatic lymph nodes are able to be differentiated from benign reactive lymph nodes by high signal intensity on the STIR sequence and diffusion restriction on DWI (Fig. 7; Table 2).32,53,54,56 Cardiac-triggered and/or respiration-triggered STIR turbo spin-echo imaging has been recommended for N-staging, and when compared with coregistered FDG-PET/CT, STIR sequence showed better performance.53 However, in another study by Yi et al,11 there were no significant differences between PET/CT and whole-body MRI in N-staging assessment. With regard to DWI, Nomori et al56 reported that DWI was significantly more accurate than FDG-PET because of less overstaging and fewer false-positive results of DWI. When the diagnostic performance of FDG-PET/CT was compared with that of FDG-PET/CT combined with DWI and T2-weighted MRI for preoperative regional lymph node evaluation, sensitivity increased from 46% to 69% with a slight decrease of specificity from 96% to 93%.32 This difference is mainly caused by inflammatory lymph nodes in which FDG uptake usually increases while there is no restricted diffusion. However, the low spatial resolution and image distortion of DWI sequences are limitations in detecting some small metastatic lymph nodes.8
Although there may be some potential gains in diagnosing lymph node metastasis with a combination of PET and MRI over PET/CT, it was not evident in preliminary studies.10,25 In a recent study that evaluated 10 patients with proven or suspected lung cancer using PET/CT followed by integrated PET/MRI, a negative lymph node was correctly diagnosed with PET/MRI, whereas PET/CT showed an FDG-avid lymph node in 1 patient.25 This difference may be caused by decreased FDG uptake in benign lymph nodes on delayed phase.
MRI provides superior soft tissue contrast in frequent extrathoracic metastatic organs from lung cancer such as the brain and liver where detection of metastasis is limited on PET/CT. Owing to these clear advantages of MRI over PET/CT in these organs, one of the most beneficial effects of PET/MRI over PET/CT in lung cancer stating may be on M-staging.57 In studies that compared whole-body MRI and PET/CT, whole-body MRI was superior in detecting brain and liver metastases and PET/CT in detecting lymph node and soft tissue metastases.11,58
Due to the high physiological FDG uptake in the brain, FDG-PET detected only 61% of the cerebral metastases that were detected with MRI.59 Although MRI of the brain embedded in whole-body MRI detected fewer brain metastases than dedicated brain MRI (27 vs. 40), all of the missed metastatic lesions by whole-body MRI were <5 mm in diameter, and all 7 patients with brain metastasis were identified with whole-body MRI.33 In addition, whole-body MRI without dedicated brain MRI was more accurate than FDG-PET/CT for the detection of brain metastases (Fig. 8).60 In a study by Lee et al,61 by adding brain MRI to PET/CT, brain metastases were detected in an additional 32 of 442 (7%) patients.
When the value of retrospective fusion of PET and gadolinium-EOB-DTPA MRI was compared with FDG-PET/CT in the detection of hepatic metastases, PET/MRI led to a significant increase in sensitivity from 76% to 93% due to the high performance of MRI.62
When whole-body MRI with DWI and PET/CT for M-staging were compared, whole-body MRI with DWI (87.7%) showed similar diagnostic performance with PET/CT (88.2%).9 Nevertheless, the strength of PET/MRI in M-staging has not been proven in preliminary studies like N-staging.10,25
Staging With Coregistered PET/MRI
The performance of an integrated PET/MRI system in lung cancer staging in a large scale has not yet been reported, but the results can be anticipated through those of coregistered PET/MRI. In a randomized comparison study between coregistered whole-body PET/MRI and PET/CT plus brain MRI, there was no significant difference between the 2 approaches in terms of correct upstaging.10 Although this study did not show the superiority of coregistered PET/MRI over PET/CT plus brain MRI, a positive interpretation would be that potentially a single modality of PET/MRI (although 2 modalities were used in this study for coregistration) could correctly upstage 25.9% of patients, which is not significantly different from the results (21.7%) of 2 modalities of PET/CT plus brain MRI. In this study, lung cancer was significantly overstaged in the PET/MRI group, whereas it was significantly understaged in the PET/CT plus brain MRI group.
Interpretation of Fusion Images in Staging
Because PET and MRI provided different aspects of the biological nature of tumors, the method of interpreting discordant results from PET and MRI in determining tumor staging has not yet been established. This decision may be dependent on the anatomic organ and clinical question. When Kim et al32 compared DWI with FDG-PET/CT to evaluate nodal staging in patients with non–small cell lung cancer, there were 10% of cases with discordant readings between the 2 modalities. In this situation, the final decision can be established by applying either inclusive (positive if either one read positive) or exclusive (positive if both read positive) criteria. Because inclusive criteria of combined PET/CT and MRI increased the sensitivity for nodal metastasis significantly from 46% to 69% compared with PET/CT alone while specificity did not significantly decrease, Kim and colleagues suggested that the number of unnecessary open thoracotomies may decrease by applying inclusive criteria and a biopsy with a less invasive method such as endobronchial ultrasound and fine-needle aspiration.
Prediction of Treatment Response
At present, the standard evaluation of treatment response of lung cancer is based on the response evaluation criteria in solid tumors, and CT is usually performed to determine the size change of tumor burden. With the development of various treatment options including targeted therapy, early determination of the treatment effect has become an important issue.
Dynamic contrast-enhanced MRI63–65 and ADC derived from DWI65–67 as well as FDG-PET68,69 have been reported to be useful markers for prediction after treatment. To assess global disease status, combined molecular and volumetric measurements of all disease sites such as metabolic tumor volume and total lesion glycolysis have been suggested.70
CHALLENGES, ADVANTAGES, AND POTENTIAL APPLICATIONS OF THE PET/MRI SYSTEM
As we are still in the very early stages of the PET/MRI system, there are many technical issues that remain to be solved, such as the relatively poor performance of PET detectors (avalanche photodiodes), MRI-based attenuation correction, limited application of techniques available in separate PET systems including the time-of-flight technique and reconstruction with 3D point spread function, and limited PET-compatible MRI coils. We are confident that these limitations will be overcome with further improvement in techniques. However, it is not clear at the moment whether the integrated PET/MRI system can provide further information than that obtained with separate PET and MRI systems despite the much higher system cost than the combined cost of each system. Further, PET/MRI may not replace PET/CT as PET/CT replaced the PET-alone systems. Finally, the operation and reading of PET/MRI can be also problematic as not only radiologists but also nuclear medicine physicians are unfamiliar and less experienced with both PET and MRI. A new customized training system may be necessary to address this issue.
Cumulative dose and its effect on imaging modalities with ionizing radiation have become a major issue, especially in children and adolescents.71 Recent investigations regarding the cancer risk of radiation dose from medical imaging in people aged 20 or younger support that there is no threshold of radiation dose in which it is safe.72,73 Given that oncologic patients usually need a series of medical imaging studies with ionizing radiation for follow-up and that radiation dose can be reduced on the PET/MRI system with lack of acquisition of CT scan, PET/MRI has a distinct strength over PET/CT, and the substitution of PET/CT with PET/MRI may be accelerated in pediatric oncologic patients who are most sensitive to radiation exposure.74 Although PET/MRI can reduce the radiation dose compared with PET/CT, there is still radiation exposure from radiotracers, which may be reduced with improvements in PET detector technology and reconstruction techniques.75
Advantages of Simultaneous Acquisition of PET/MRI Over Separate PET and MRI Acquisition
Total examination time can be reduced with simultaneous acquisition rather than with a sequential acquisition system or separate systems. In oncologic imaging, the exact information of organ movement through simultaneous acquisition can result in better matching of lesions identified on MRI and PET and can improve accurate SUV calculation. The use of simultaneous dynamic PET/MRI can cross-validate the change of perfusion status with each modality, and kinetic PET data modeling can be performed using an MRI-derived arterial input function.26
As PET/MRI can noninvasively provide in vivo quantitative data regarding pharmacokinetics and pharmacodynamics of novel therapeutic agents of interest, it may be useful for optimizing drug development.75 Prior studies have shown that an intratumoral concentration of 5-fluorouracil and its metabolites could be measured by either 18F PET29 or 19F MR spectroscopy.76 Contrary to current assessment of pharmacokinetics and pharmacodynamics in blood, body secretion, or biopsy specimens, PET/MRI is expected to allow in vivo real-time measurement of pharmacokinetics and pharmacodynamics of drugs and its metabolites at target tissue in conjunction with the use of radioactively labeled 11C, 18F isotopes for PET, and 1H, 13C, and 19F for MR spectroscopy. PET/MRI has the potential not only to reveal individual variability of drug response but also to identify patients likely to respond to chemotherapy, although in vivo simultaneous evaluation of pharmacokinetics and pharmacodynamics using PET/MRI remains in the proof-of-concept stage and needs to be guaranteed by many more investigations.
With improvements in imaging technology, various imaging modalities and radiotracers can now provide valuable information regarding tumor characteristics, but the results from individual modalities are discordant at the regional or whole-tumor level. Anatomically and temporally matched PET/MRI that can provide various molecular and functional information at the same time has the potential to reveal and characterize the biological properties of tumors such as tumor perfusion, metabolism, and hypoxia through multiparametric imaging.77 In the era of targeted therapy, it is difficult to properly capture tumor response by conventional morphologic criteria as the effect of therapy targeting tumor vasculature is focused on the decrease of blood supply and neoangiogenesis to the tumor rather than a decrease in tumor size.78 A preclinical study has already demonstrated that PET/MRI has the potential to assess the heterogeneity of the tumor microenvironment, which consists of tumor necrosis, hypoxia, and well-perfused lesions.79 Given that tumor hypoxia is related to aggressive tumor behavior enhancing metastasis and resistance to chemoradiotherapy,80,81 PET/MRI scans at baseline workup and during the follow-up period are expected to help predict treatment response earlier and to evaluate the heterogeneity of the tumor microenvironment.
PET/MRI may serve as an appealing tool over PET/CT for workup of patients with lung cancer in terms of contrast resolution, multiparametric imaging, and radiation dose (Table 3). It can offer a potential “one-stop” imaging modality in the evaluation of the whole-body status of lung cancer. Although as of now there may be a paucity of studies examining the utility of PET/MRI, future research studies may demonstrate the value of PET/MRI in lung cancer evaluation.
1. Beyer T, Townsend DW, Brun T, et al..A combined PET/CT scanner for clinical oncology.J Nucl Med.2000;41:1369–1379.
2. Wechalekar K, Sharma B, Cook G.PET/CT in oncology—a major advance.Clin Radiol.2005;60:1143–1155.
3. Antoch G, Vogt FM, Freudenberg LS, et al..Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology.JAMA.2003;290:3199–3206.
4. Bar-Shalom R, Yefremov N, Guralnik L, et al..Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management.J Nucl Med.2003;44:1200–1209.
5. Fischer B, Lassen U, Mortensen J, et al..Preoperative staging of lung cancer with combined PET-CT.N Engl J Med.2009;361:32–39.
6. Shim SS, Lee KS, Kim BT, et al..Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging.Radiology.2005;236:1011–1019.
7. Schreyogg J, Weller J, Stargardt T, et al..Cost-effectiveness of hybrid PET/CT for staging of non-small cell lung cancer.J Nucl Med.2010;51:1668–1675.
8. Koyama H, Ohno Y, Seki S, et al..Magnetic resonance imaging for lung cancer.J Thorac Imaging.2013;28:138–150.
9. Ohno Y, Koyama H, Onishi Y, et al..Non-small cell lung cancer: whole-body MR examination for M-stage assessment—utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT.Radiology.2008;248:643–654.
10. Yi CA, Lee KS, Lee HY, et al..Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer: Comparisons of clinical effectiveness in a randomized trial.Cancer.2013;119:1784–1791.
11. Yi CA, Shin KM, Lee KS, et al..Non-small cell lung cancer staging: efficacy comparison of integrated PET/CT versus 3.0-T whole-body MR imaging.Radiology.2008;248:632–642.
12. Zaidi H, Montandon ML, Alavi A.The clinical role of fusion imaging using PET, CT, and MR imaging.Magn Reson Imaging Clin N Am.2010;18:133–149.
13. Herzog H.PET/MRI: challenges, solutions and perspectives.Z Med Phys.2012;22:281–298.
14. Zaidi H, Del Guerra A.An outlook on future design of hybrid PET/MRI systems.Med Phys.2011;38:5667–5689.
15. Delso G, Furst S, Jakoby B, et al..Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner.J Nucl Med.2011;52:1914–1922.
16. Wurslin C, Schmidt H, Martirosian P, et al..Respiratory motion correction in oncologic PET using T1-weighted MR imaging on a simultaneous whole-body PET/MR system.J Nucl Med.2013;54:464–471.
17. Slomka PJ, Baum RP.Multimodality image registration with software: state-of-the-art.Eur J Nucl Med Mol Imaging.2009;36suppl 1S44–S55.
18. Shan ZY, Mateja SJ, Reddick WE, et al..Retrospective evaluation of PET-MRI registration algorithms.J Digit Imaging.2011;24:485–493.
19. Hofmann M, Pichler B, Scholkopf B, et al..Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques.Eur J Nucl Med Mol Imaging.2009;36suppl 1S93–S104.
20. Martinez-Moller A, Souvatzoglou M, Delso G, et al..Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data.J Nucl Med.2009;50:520–526.
21. Schulz V, Torres-Espallardo I, Renisch S, et al..Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data.Eur J Nucl Med Mol Imaging.2011;38:138–152.
22. Keereman V, Holen RV, Mollet P, et al..The effect of errors in segmented attenuation maps on PET quantification.Med Phys.2011;38:6010–6019.
23. Hofmann M, Bezrukov I, Mantlik F, et al..MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentation- and atlas-based methods.J Nucl Med.2011;52:1392–1399.
24. Drzezga A, Souvatzoglou M, Eiber M, et al..First clinical experience with integrated whole-body PET/MR: comparison to PET/CT in patients with oncologic diagnoses.J Nucl Med.2012;53:845–855.
25. Schwenzer NF, Schraml C, Muller M, et al..Pulmonary lesion assessment: comparison of whole-body hybrid MR/PET and PET/CT imaging—pilot study.Radiology.2012;264:551–558.
26. Bailey DL, Barthel H, Beyer T, et al..Summary Report of the First International Workshop on PET/MR Imaging, March 19-23, 2012, Tubingen, Germany.Mol Imaging Biol.2013;15:361–371.
27. Brendle CB, Schmidt H, Fleischer S, et al..Simultaneously acquired MR/PET images compared with sequential MR/PET and PET/CT: alignment quality.Radiology.2013;268:190–199.
28. Lois C, Bezrukov I, Schmidt H, et al..Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging.Eur J Nucl Med Mol Imaging.2012;39:1756–1766.
29. Hoetjes NJ, van Velden FH, Hoekstra OS, et al..Partial volume correction strategies for quantitative FDG PET in oncology.Eur J Nucl Med Mol Imaging.2010;37:1679–1687.
30. Martinez-Moller A, Eiber M, Nekolla SG, et al..Workflow and scan protocol considerations for integrated whole-body PET/MRI in oncology.J Nucl Med.2012;53:1415–1426.
31. Zenge MO, Vogt FM, Brauck K, et al..High-resolution continuously acquired peripheral MR angiography featuring partial parallel imaging GRAPPA.Magn Reson Med.2006;56:859–865.
32. Kim YN, Yi CA, Lee KS, et al..A proposal for combined MRI and PET/CT interpretation criteria for preoperative nodal staging in non-small-cell lung cancer.Eur Radiol.2012;22:1537–1546.
33. Thomson V, Pialat JB, Gay F, et al..Whole-body MRI for metastases screening: a preliminary study using 3D VIBE sequences with automatic subtraction between noncontrast and contrast enhanced images.Am J Clin Oncol.2008;31:285–292.
34. Hamm B, Mahfouz AE, Taupitz M, et al..Liver metastases: improved detection with dynamic gadolinium-enhanced MR imaging?Radiology.1997;202:677–682.
35. Van Dijk P, Sijens PE, Schmitz PI, et al..Gd-enhanced MR imaging of brain metastases: contrast as a function of dose and lesion size.Magn Reson Imaging.1997;15:535–541.
36. Smirniotopoulos JG, Murphy FM, Rushing EJ, et al..Patterns of contrast enhancement in the brain and meninges.Radiographics.2007;27:525–551.
37. Biederer J, Schoene A, Freitag S, et al..Simulated pulmonary nodules implanted in a dedicated porcine chest phantom: sensitivity of MR imaging for detection.Radiology.2003;227:475–483.
38. Schroeder T, Ruehm SG, Debatin JF, et al..Detection of pulmonary nodules using a 2D HASTE MR sequence: comparison with MDCT.AJR Am J Roentgenol.2005;185:979–984.
39. Frericks BB, Meyer BC, Martus P, et al..MRI of the thorax during whole-body MRI: evaluation of different MR sequences and comparison to thoracic multidetector computed tomography (MDCT).J Magn Reson Imaging.2008;27:538–545.
40. Bruegel M, Gaa J, Woertler K, et al..MRI of the lung: value of different turbo spin-echo, single-shot turbo spin-echo, and 3D gradient-echo pulse sequences for the detection of pulmonary metastases.J Magn Reson Imaging.2007;25:73–81.
41. Chandarana H, Heacock L, Rakheja R, et al..Pulmonary nodules in patients with primary malignancy: comparison of hybrid PET/MR and PET/CT imaging.Radiology.2013;268:874–881.
42. Siegel MJ, Acharyya S, Hoffer FA, et al..Whole-body MR imaging for staging of malignant tumors in pediatric patients: results of the American College of Radiology Imaging Network 6660 Trial.Radiology.2013;266:599–609.
43. Choi SH, Kim YT, Kim SK, et al..Positron emission tomography-computed tomography for postoperative surveillance in non-small cell lung cancer.Ann Thorac Surg.2011;92:1826–1832.
44. Goo JM, Im JG, Do KH, et al..Pulmonary tuberculoma evaluated by means of FDG PET: findings in 10 cases.Radiology.2000;216:117–121.
45. Chun EJ, Lee HJ, Kang WJ, et al..Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: the feasibility of integrated (18)F-FDG PET/CT.Lung Cancer.2009;65:180–186.
46. UyBico SJ, Wu CC, Suh RD, et al..Lung cancer staging essentials: the new TNM staging system and potential imaging pitfalls.Radiographics.2010;30:1163–1181.
47. Padovani B, Mouroux J, Seksik L, et al..Chest wall invasion by bronchogenic carcinoma: evaluation with MR imaging.Radiology.1993;187:33–38.
48. Sakai S, Murayama S, Murakami J, et al..Bronchogenic carcinoma invasion of the chest wall: evaluation with dynamic cine MRI during breathing.J Comput Assist Tomogr.1997;21:595–600.
49. Ohno Y, Adachi S, Motoyama A, et al..Multiphase ECG-triggered 3D contrast-enhanced MR angiography: utility for evaluation of hilar and mediastinal invasion of bronchogenic carcinoma.J Magn Reson Imaging.2001;13:215–224.
50. Lee CH, Goo JM, Kim YT, et al..The clinical feasibility of using non-breath-hold real-time MR-echo imaging for the evaluation of mediastinal and chest wall tumor invasion.Korean J Radiol.2010;11:37–45.
51. Plathow C, Aschoff P, Lichy MP, et al..Positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced nonsmall cell lung cancer—initial results.Invest Radiol.2008;43:290–297.
52. Kim HY, Yi CA, Lee KS, et al..Nodal metastasis in non-small cell lung cancer: accuracy of 3.0-T MR imaging.Radiology.2008;246:596–604.
53. Ohno Y, Koyama H, Nogami M, et al..STIR turbo SE MR imaging vs. coregistered FDG-PET/CT: quantitative and qualitative assessment of N-stage in non-small-cell lung cancer patients.J Magn Reson Imaging.2007;26:1071–1080.
54. Ohno Y, Hatabu H, Takenaka D, et al..Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative and qualitative assessment with STIR turbo spin-echo MR imaging.Radiology.2004;231:872–879.
55. Ohno Y, Koyama H, Yoshikawa T, et al..N stage disease in patients with non-small cell lung cancer: efficacy of quantitative and qualitative assessment with STIR turbo spin-echo imaging, diffusion-weighted MR imaging, and fluorodeoxyglucose PET/CT.Radiology.2011;261:605–615.
56. Nomori H, Mori T, Ikeda K, et al..Diffusion-weighted magnetic resonance imaging can be used in place of positron emission tomography for N staging of non-small cell lung cancer with fewer false-positive results.J Thorac Cardiovasc Surg.2008;135:816–822.
57. Buchbender C, Heusner TA, Lauenstein TC, et al..Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis.J Nucl Med.2012;53:928–938.
58. Schmidt GP, Baur-Melnyk A, Tiling R, et al..Comparison of high resolution whole-body MRI using parallel imaging and PET-CT. First experiences with a 32-channel MRI system.Radiologe.2004;44:889–898.
59. Rohren EM, Provenzale JM, Barboriak DP, et al..Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy.Radiology.2003;226:181–187.
60. Schmidt GP, Baur-Melnyk A, Herzog P, et al..High-resolution whole-body magnetic resonance image tumor staging with the use of parallel imaging versus dual-modality positron emission tomography-computed tomography: experience on a 32-channel system.Invest Radiol.2005;40:743–753.
61. Lee HY, Lee KS, Kim BT, et al..Diagnostic efficacy of PET/CT plus brain MR imaging for detection of extrathoracic metastases in patients with lung adenocarcinoma.J Korean Med Sci.2009;24:1132–1138.
62. Donati OF, Hany TF, Reiner CS, et al..Value of retrospective fusion of PET and MR images in detection of hepatic metastases: comparison with 18F-FDG PET/CT and Gd-EOB-DTPA-enhanced MRI.J Nucl Med.2010;51:692–699.
63. Ohno Y, Nogami M, Higashino T, et al..Prognostic value of dynamic MR imaging for non-small-cell lung cancer patients after chemoradiotherapy.J Magn Reson Imaging.2005;21:775–783.
64. Chang YC, Yu CJ, Chen CM, et al..Dynamic contrast-enhanced MRI in advanced nonsmall-cell lung cancer patients treated with first-line bevacizumab, gemcitabine, and cisplatin.J Magn Reson Imaging.2012;36:387–396.
65. Yabuuchi H, Hatakenaka M, Takayama K, et al..Non-small cell lung cancer: detection of early response to chemotherapy by using contrast-enhanced dynamic and diffusion-weighted MR imaging.Radiology.2011;261:598–604.
66. Chang Q, Wu N, Ouyang H, et al..Diffusion-weighted magnetic resonance imaging of lung cancer at 3.0 T: a preliminary study on monitoring diffusion changes during chemoradiation therapy.Clin Imaging.2012;36:98–103.
67. Ohno Y, Koyama H, Yoshikawa T, et al..Diffusion-weighted MRI versus 18F-FDG PET/CT: performance as predictors of tumor treatment response and patient survival in patients with non-small cell lung cancer receiving chemoradiotherapy.Am J Roentgenol.2012;198:75–82.
68. Weber WA, Petersen V, Schmidt B, et al..Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use.J Clin Oncol.2003;21:2651–2657.
69. Lee DH, Kim SK, Lee HY, et al..Early prediction of response to first-line therapy using integrated 18F-FDG PET/CT for patients with advanced/metastatic non-small cell lung cancer.J Thorac Oncol.2009;4:816–821.
70. Moon SH, Hyun SH, Choi JY.Prognostic significance of volume-based PET parameters in cancer patients.Korean J Radiol.2013;14:1–12.
71. Ahmed BA, Connolly BL, Shroff P, et al..Cumulative effective doses from radiologic procedures for pediatric oncology patients.Pediatrics.2010;126:e851–e858.
72. Mathews JD, Forsythe AV, Brady Z, et al..Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians.BMJ.2013;346:f2360.
73. Pearce MS, Salotti JA, Little MP, et al..Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.Lancet.2012;380:499–505.
74. Hirsch FW, Sattler B, Sorge I, et al..PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner.Pediatr Radiol.2013;43:860–875.
75. Torigian DA, Zaidi H, Kwee TC, et al..PET/MR imaging: technical aspects and potential clinical applications.Radiology.2013;267:26–44.
76. Presant CA, Wolf W, Waluch V, et al..Association of intratumoral pharmacokinetics of fluorouracil with clinical response.Lancet.1994;343:1184–1187.
77. Padhani AR, Miles KA.Multiparametric imaging of tumor response to therapy.Radiology.2010;256:348–364.
78. van Persijn van Meerten EL, Gelderblom H, Bloem JL.RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline.Eur Radiol.2010;20:1456–1467.
79. Cho H, Ackerstaff E, Carlin S, et al..Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.Neoplasia.2009;11:247–259.
80. Mankoff DA, Dunnwald LK, Partridge SC, et al..Blood flow-metabolism mismatch: good for the tumor, bad for the patient.Clin Cancer Res.2009;15:5294–5296.
81. Horsman MR, Mortensen LS, Petersen JB, et al..Imaging hypoxia to improve radiotherapy outcome.Nat Rev Clin Oncol.2012;9:674–687.
positron emission tomography; magnetic resonance imaging; positron emission tomography and computed tomography; lung cancer; review
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