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Myocardial Tissue Characterization by Magnetic Resonance Imaging: Novel Applications of T1 and T2 Mapping

Ferreira, Vanessa M. MD, DPhil; Piechnik, Stefan K. PhD, MscEE; Robson, Matthew D. PhD; Neubauer, Stefan MD; Karamitsos, Theodoros D. PhD

Journal of Thoracic Imaging:
doi: 10.1097/RTI.0000000000000077
Symposium Review Articles
Open Access

Cardiac magnetic resonance (CMR) imaging is a well-established noninvasive imaging modality in clinical cardiology. Its unsurpassed accuracy in defining cardiac morphology and function and its ability to provide tissue characterization make it well suited for the study of patients with cardiac diseases. Late gadolinium enhancement was a major advancement in the development of tissue characterization techniques, allowing the unique ability of CMR to differentiate ischemic heart disease from nonischemic cardiomyopathies. Using T2-weighted techniques, areas of edema and inflammation can be identified in the myocardium. A new generation of myocardial mapping techniques are emerging, enabling direct quantitative assessment of myocardial tissue properties in absolute terms. This review will summarize recent developments involving T1-mapping and T2-mapping techniques and focus on the clinical applications and future potential of these evolving CMR methodologies.

Author Information

Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, Oxford, UK

US patent pending 61/387,591: Stefan K. Piechnik and Matthew D. Robson. Systems and methods for shortened look-locker inversion recovery (ShMOLLI) cardiac gated mapping of T1. September 29, 2010. All rights sold exclusively to Siemens Medical Solutions. US patent pending 61/689,067: Stefan K. Piechnik and Matthew D. Robson. Color map design method for immediate assessment of the deviation from established normal population statistics and its application to cardiovascular T1 mapping images. The remaining authors declare no conflicts of interest.

Reprints: Theodoros D. Karamitsos, PhD, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK (e-mail:

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© 2014 by Lippincott Williams & Wilkins