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Therapy-related Noninfectious Complications in Patients With Hematologic Malignancies: High-resolution Computed Tomography Findings

Brodoefel, Harald MD*; Faul, Christoph MD; Salih, Helmut MD; Vogel, Wolfgang MD; Fenchel, Michael MD*,‡; Horger, Marius MD*

Journal of Thoracic Imaging:
doi: 10.1097/RTI.0b013e31822031f0
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Pulmonary complications are a leading source of mortality in patients treated for hematologic malignancies. After hematopoietic stem cell transplantation, treatment-related noninfectious complications constitute more than half of the pulmonary pathology and represent a particular diagnostic challenge. This review illustrates the high-resolution computed tomography findings of common therapy-related complications and thereby demonstrates a high degree of overlap between the patterns of various toxicities. Clinical background knowledge of the distinct entities is reviewed and highlighted as an indispensable instrument to narrow the differential diagnosis.

Author Information

Departments of *Diagnostic and Interventional Radiology

Internal Medicine-Oncology and Hematology

Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, Tübingen, Germany

The authors declare no conflicts of interest.

Reprints: Harald Brodoefel, MD, Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany (e-mail:

© 2013 Lippincott Williams & Wilkins, Inc.