Since the publication of the National Lung Screening Trial results, there has been increasing interest among radiologists to establish computed tomography (CT) screening centers. During the past 10 years, we have operated a CT screening center in suburban Boston, MA. The purpose of this paper is to describe our process for performing self-referred CT lung screening exams, including our organizational structure, marketing, patient selection process, and standardized workflow. Direct communication between the patient and radiologist, both before and after the CT scan, in our opinion, is critical to a successful screening program. In many ways, CT screening offers radiologists a wonderful opportunity to interact directly with patients. Showing abnormal lung findings to patients on their CT scans may help create a unique “teachable” moment for current smokers and may help motivate patients to quit smoking.