Systemic mastocytosis is an uncommon disease of unknown prevalence. Most patients clinically present with urticaria pigmentosa. The diagnosis is made by finding increased mast cells in the involved tissues. Pulmonary involvement in systemic mastocytosis is rare. The chest radiographic findings include reticulonodular opacities and lung nodules. We present a case of histologically proven pulmonary and skeletal systemic mastocytosis (AKA systemic mast cell disease) associated with a hematologic condition, including the high-resolution computed tomographic findings of this disorder.
Systemic mastocytosis is a rare disorder of unknown etiology. The most commonly affected tissue systems are the skin, lymph nodes, gastrointestinal system, and bone marrow. Pulmonary involvement is rare. We present the high resolution computed tomographic (HRCT) and chest radiographic findings in a patient with systemic mastocytosis with histologically proven pulmonary involvement.