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Adenocarcinoma of the Male Breast after Spironolactone-Induced Gynecomastia: Case Report.

Wilson, Rodman M.D.; Lanier, James M.D.
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A man was given spironolactone and other drugs intermittently for control of hypertension. He developed gynecomastia bilaterally; spironolactone was stopped. Three years later, fatal infiltrating ductal adenocarcinoma of the breast supervened. This sequence of events raises suspicion that spironolactone therapy led to lethal breast carcinoma.

(C) Lippincott-Raven Publishers.