Skip Navigation LinksHome > March 2012 - Volume 11 - Issue 1 > Role of Platelet-derived Growth Factor in Hindfoot Fusion
Techniques in Foot & Ankle Surgery:
doi: 10.1097/BTF.0b013e3182469626
Special Focus: Role of Platelet-Rich Plasma and rhPDGF in Foot and Ankle Surgery

Role of Platelet-derived Growth Factor in Hindfoot Fusion

Glazebrook, Mark MSc, PhD, MD, FRCS(C), Dip Sports Med.*; Daniels, Timothy R. MD, FRCS(C); Abidi, Nicholas A. MD; Younger, Alastair MSc MD, FRCSC§; DiGiovanni, Christopher W. MD

Collapse Box

Abstract

Bone healing that is orchestrated by osteoblasts and osteoclasts is regulated by a complex interaction between biochemical factors such as cytokines and growth factors. One of the critical early growth factors that have an influence on healing is platelet-derived growth factor (PDGF). PDGF is a family of polypeptides that has the ability to attract and stimulate the metabolic activity of mesenchymal cells, stimulating a repair process that includes increased bone formation. Recently, a fully synthetic bone graft material composed of recombinant human platelet-derived growth factor and a β-tricalcium phosphate matrix under the name Augment Bone Graft was shown to be a safe alternative to autogenous bone graft for hindfoot fusion operations. This review provides an overview of the role of PDGF in the biology of bone healing and examines the clinical utility and most recent literature regarding efficacy of the use of PDGF as a safe alternative to autogenous bone graft for hindfoot fusion operations. Finally, the surgical procedure of ankle arthrodesis is described as an example of how PDGF may be used for surgical treatment of end-stage hindfoot arthritis.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.