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The Association Between HIV Infection and Alcohol Use: A Systematic Review and Meta-Analysis of African Studies

Fisher, Joseph C. PhD, MPH*; Bang, Heejung PhD†; Kapiga, Saidi H. MD, MPH, ScD‡

doi: 10.1097/OLQ.0b013e318067b4fd
Review

To summarize the association between alcohol use and human immunodeficiency virus (HIV) infection based on studies conducted in Africa, EMBASE and PubMed were searched for African studies that related alcohol use to HIV infection. Meta-analyses were conducted to obtain pooled univariate and multivariate relative risk estimates. Subgroup analyses were performed for studies having different sample types: males or females and population-based or high-risk, and ones that differentiated between problem and asymptomatic drinkers. Alcohol drinkers were more apt to be HIV+ than nondrinkers. The pooled unadjusted odds ratio (OR) from 20 studies was 1.70 (95% confidence interval, CI = 1.45–1.99). Results from 11 studies that adjusted for other risk factors produced a pooled risk estimate of 1.57 (95% CI = 1.42–1.72). Males and females had similar risk estimates, while studies involving high-risk samples tended to report larger pooled odds ratios than studies of the general population. When compared with nondrinkers, the pooled estimates of HIV risk were 1.57 (95% CI = 1.33–1.86) for nonproblem drinkers versus 2.04 (95% CI = 1.61–2.58) for problem drinkers, a statistically significant difference (z = 2.08, P <0.04). Alcohol use was associated with HIV infection in Africa and alcohol-related interventions might help reduce further expansion of the epidemic.

A systematic review and meta-analysis of published literature confirms that alcohol consumption is an important risk factor for HIV infection in sub-Saharan Africa.

From *Interdata, Inc, Sanibel, Florida; †Department of Public Health, Division of Biostatistics and Epidemiology, Weill Medical College of Cornell University, New York, New York; and ‡Department of Population and International Health, Harvard School of Public Health, Boston, Massachusetts

The authors would like to acknowledge the contribution of Trong Ao during the literature review.

Correspondence: Joseph C. Fisher, PhD, MPH, Interdata, Inc., PO Box 129, Sanibel, FL 33957. E-mail: jofisher@post.harvard.edu.

Received for publication October 29, 2006, and accepted March 31, 2007.

BY THE END OF 2006, 40 million people worldwide were living with human immunodeficiency virus (HIV), and the majority of these, 25 million, reside in sub-Saharan Africa.1 Without effective measures to treat the disease and address its spread, countries in the region face a demographic and economic catastrophe of staggering dimensions as evidenced by increasing acquired immunodeficiency virus (AIDS)-related morbidity and mortality and decreasing life expectancy at birth. The World Health Organization estimates that the current life expectancy in the sub-Saharan region of 43 years at birth would be 56 years in the absence of the epidemic, and that 1 in 5 deaths annually in Africa is attributable to acquired immunodeficiency virus.2,3

Moreover, despite stabilizing and declining trends in some countries, notably Uganda, the HIV epidemic is expanding rapidly in most parts of the region. Southern Africa is the worst affected area, with prevalence of HIV among sexually active adults ranging between 20% and 40% in most countries where the epidemic is generalized.1 The prevalence of infection among adults is typically around 10% in countries of Central African region, and 5% or higher in 3 West African countries of Bukina Faso, Cote d’Ivore, and Nigeria.

The search for effective interventions to reduce further expansion of the epidemic and mitigate its social and economic impact continues to be therefore the most important public health priority in sub-Saharan Africa. To this end, improved understanding of the behavioral risk factors that amplify the force of the infection is critical in the design of effective interventions and in targeting interventions to people at highest risk of infection.

One behavior that may be implicated in the transmission of HIV and other sexually transmitted diseases (STDs) is alcohol consumption. A recent systematic review of published literature found problematic alcohol consumption was associated with increased risk of STDs.4 The contribution of alcohol drinking to HIV transmission has not been systematically examined, and most intervention programs neglect the potential role of alcohol consumption as an intermediate variable, which may influence behaviors related to HIV. To address these omissions and to quantify the association between alcohol drinking behavior and HIV infection, we conducted a systematic review of the scientific literature and a meta-analysis of the reported risks associated with alcohol use and HIV based on studies conducted in Africa.

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Methods

Literature Search

Figure 1 summarizes the process for selecting articles included in the meta-analysis. Initially, EMBASE and PubMed databases were searched to identify studies conducted in Africa that related alcohol use to HIV infection. To expand the scope of the enumeration the search was repeated for alcohol use and sexually transmitted infections (STIs) and again for alcohol and STDs. In all the 5 separate searches identified 250 unduplicated references, 96 from PubMed and 66 from EMBASE uniquely, and 88 that appeared in both databases.

Titles and abstracts for the unduplicated references were reviewed and 77 of 250 articles were retained after meeting the following criteria: 1) reported original, empirical research published in a peer review journal, and 2) considered alcohol use or drinking behavior as a potential risk factor for HIV infection. Studies of HIV risk factors such as presence of other STIs, high-risk sexual behavior, and sexual violence were included in the review in case any reported rates of HIV infection among drinkers and nondrinkers.

Out of 77 studies reviewed, 20 provided data that could be used in the meta-analysis. These studies either reported odds ratios (ORs) comparing drinkers and nondrinkers about HIV prevalence and/or seroconversion, or a contingency table from which the ORs could be calculated. A list of the studies used in the analysis and a digest of the information extracted from them is given in Table 1.

Eighteen of the studies are cross-sectional and hence measured the relationship between alcohol use and HIV prevalence in the sample, whereas 25,6 are prospective and examined HIV transmission among drinkers and nondrinkers. Additionally, 2 types of samples were encountered: representative samples from community-based surveys5,7–14 and samples of high-risk groups such as bar and hotel workers,15,16 sailors,17 miners,14 beer hall patrons,18 pregnant women and mothers,6,19,20 and people seeking treatment in health facilities.21–24 Perhaps most significantly, all the studies represented were conducted in East Africa and Southern Africa.

Three studies in addition to those listed in Table 1, although they did not report data that could be used in the meta-analysis, provided evidence of a positive relationship between alcohol use and HIV status, risk, or transmission. These include an investigation of HIV prevalence and high alcohol consumption levels among female recreation workers in Tanzania,25 an ecological analysis in Tanzania relating local alcohol use with HIV prevalence rates,26 and a Rwandan study that associated HIV status of a woman with alcohol use of her partner.27

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Data

Measures of alcohol use were not consistent across studies. Drinking was indicated by quantity and frequency consumed, standardized diagnostic instrument of problem drinking (e.g., CAGE, AUDIT), or by attending bars or selling alcohol at home. The time period measured also was not uniform, some studies asked about recent drinking, past week as an example, whereas others used an ever use/never use dichotomy. For purposes of the analysis then the criterion was alcohol use, yes or no, regardless of the time period covered and the outcome was the binary variable HIV status, positive or negative.

A second reader independently verified the extracted data. The data obtained were quite simple and no standardized coding form was needed or used. The coders were not masked to the journals or authors of the studies reviewed. There were no conflicts between the coders in the classification of the extracted data.

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Statistical Analyses

The meta-analysis was guided by the checklist proposed by the Meta-analysis of Observational Studies in Epidemiology (MOOSE) Group.28 Weighted summary measures were computed as ORs with 95% confidence intervals (CIs), calculated by the DerSimonian and Laird’s random-effects model,29 where OR was chosen to make the statistical measure for each study consistent. Evidence of publication bias was investigated by means of funnel plot and 2 different tests proposed by Begg and Mazumdar30 based on rank correlation (after continuity correction) and by Egger et al.31 Heterogeneity was quantitatively assessed using the Cochran’s Q statistics and also visually examined through the L’Abbe plot32 (not shown).

Meta-analyses of univariate ORs and multivariate adjusted odds ratios (AORs) were performed and forest plots were used to visualize individual as well as the pooled effects. As a sensitivity analysis, we implemented the trim and fill method33 to account for publication bias that was hidden or undetected by standard statistical test.

To address the effects of important study characteristics, we additionally conducted several subgroup analyses, by: sex of subjects in the sample (male vs. females) and type of sample (population based vs. high risk).

The primary analysis combined studies having disparate definitions of alcohol consumption. To further specify the relationship of interest the analysis was repeated with the subset of studies (7) that rigorously defined alcohol use and differentiated between problem and nonproblem drinkers. Standard definitions of problem drinking used to categorize drinkers were: quantity, ≥3 drinks per occasion;23 frequency, daily consumption;9,11,14,16 and diagnostic instrument scores (CAGE, AUDIT).15,22

A 2-sided hypothesis was employed in all statistical testing and CI construction. Statistical and graphical analyses were carried out by STATA version 8.2.34

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Results

Primary Analyses

The results of all the analyses are summarized in Table 2, while Figure 2 displays the primary analyses using crude ORs. Univariate analysis of the association between alcohol consumption and HIV infection shows that alcohol users have significantly higher odds of being HIV-positive (pooled OR = 1.70; 95% CI = 1.45–1.99; P value <0.001). The test of heterogeneity was highly significant with P value <0.001, whereas publication bias was not detected (P value = 0.67 and 0.12 by Begg and Mazumdar’s and Egger et al.’s tests, respectively).30,31

Next, as a confirmatory measure, we repeated the analyses implementing a trim and fill methodology that accounts for potential publication bias that might not have been evident in our original investigation but still might exist. This method rank-orders the ORs and determines from the gaps in the distribution the number of studies that may potentially have been excluded because of publication bias. Hypothetical results are created to correct for these possible omissions and the pooled OR is computed on the larger sample of studies. Applying this method to the univariate ORs, 5 negative studies were estimated to be missing and results for them were created artificially. Based on analysis of this expanded study sample, alcohol drinkers remained at relatively increased risk when compared with nondrinkers (OR = 1.48; 95% CI = 1.26–1.73; P value <0.001).

The same analysis was repeated among 11 studies that reported multivariable AORs for the association between alcohol use and HIV infection; the results are summarized in Table 2 and Figure 3. In this analysis the association between HIV infection and alcohol use was attenuated to OR = 1.57 (95% CI = 1.42–1.72; P value <0.001). Heterogeneity among studies was no longer significant (P = 0.60) and again publication bias was not significant (P = 0.34–0.43). After applying the trim and fill methodology and filling 3 studies that could have been omitted, the results were largely unchanged (OR = 1.52; 95% CI = 1.39–1.66; P value < 0.001).

Funnel plots that aid assessment of publication bias are presented in Figure 4.

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Subgroup Analyses

To examine what effect study characteristics might have on the results, we analyzed subgroups of studies defined by sample characteristics, by gender and if the sample was high risk or population based (Table 2). About the former when we first compared all studies with homogenous samples of either males (10 studies) or females (16 studies) the magnitudes of association were nearly identical, OR = 1.91 (95% CI = 1.57–2.33) and OR = 1.90 (95% CI = 1.68–2.19), respectively.

We repeated this analysis restricting the sample to studies that reported results for both males and females. The same study restriction tends to eliminate potential sources of bias such as geography, time, and alcohol measurement. Analysis of the 8 studies that fit this criterion produced pooled ORs that were more discrepant but still not meaningfully different: males OR = 1.98 (95% CI = 1.76–2.22) and females OR = 1.78 (95% CI = 1.53–2.08).

Alcohol use was associated with significantly higher odds of being HIV-positive for both types of samples, population based (OR = 1.77; 95% CI = 1.62–1.93) and high-risk groups (OR = 2.01; 95% CI = 1.56–2.58), where the latter group showed a stronger association as anticipated (z = 1.91, P <0.06).

Problem drinkers were at greater risk to be HIV+ (Table 2) than were drinkers who did not use alcohol symptomatically (z = 2.08, P <0.04). When compared with nondrinkers, the pooled estimates of HIV risk was 1.57 (95% CI = 1.33–1.86) for nonproblem alcohol drinkers and 2.04 (95% CI = 1.61–2.58) for problem drinkers.

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Discussion

We identified 20 studies that examined the association between alcohol consumption and HIV infection in Africa. Based on a systematic review and meta-analysis, we observed evidence of a strong relationship between alcohol use and HIV infection. Drinkers have a 70% greater chance of being HIV positive when compared with nondrinkers in the bivariate case, and a 57% increased risk of HIV infection when potential confounders were controlled in multivariate analysis. The association remained strong and consistent after adjustment for possible publication bias with elevated risks of alcohol use ranging from 48% to 52% for the univariate and multivariate pooled risk estimates respectively.

This conclusion is further supported by 3 additional findings of the analysis. First, as shown in the plots of the effects by study, there is strong consistency and agreement in the estimated effect measures across studies, particularly for studies reporting a multivariate AOR. Second, risk estimates are comparable across different types of samples, for males and females and for high-risk and representative populations. Third, alcohol use demonstrates a crude dose–response relationship with HIV infection such that the heaviest and symptomatic drinkers are at greater risk to be HIV+ than are more moderate drinkers and those who do not experience problems as a result of drinking. Taken together, these results provide strong evidence supporting the role of alcohol drinking as a risk factor for HIV infection.

These findings and conclusions should be interpreted in light of a number of limitations of our analysis. With exception of 2 reports all studies we examined were cross-sectional and it is not possible to determine if a causal relationship between alcohol use and HIV infection exists. An equally plausible explanation for some or all of the observed association is that people living with HIV drink more to cope with their circumstance. Results from the 2 prospective studies conducted in Uganda5 and Tanzania6 did show, however, that drinking was strongly related to increased risk of HIV acquisition (incidence rate ratio = 1.89; 95% CI = 1.59–2.26 and incidence rate ratio = 2.61; 95% CI = 1.63–4.16, respectively). In both studies the relationship remained after adjustment for other factors in multivariate regression analysis.

Every meta-analysis is subject to publication bias because nonsignificant findings are less apt to make their way into print.35 This problem is exacerbated when statistical models are employed because customarily only significant terms are reported. In our case nonsignificant results from at least 3 studies7,9,22 could not be included in the multivariate meta-analysis for this reason. To partially remedy the problem, we adopted a trim and fill methodology to simulate the effect of missing studies on the pooled estimates. The association between alcohol use and HIV status may be overstated nonetheless.

It is important to note that significant heterogeneity exists in the unadjusted analysis. Given this situation combining the effects may not be justified. However, we also note that the adjusted analysis, subgroup and problem drinker analyses did not exhibit the heterogeneity observed among the univariate ORs. Results of these analyses gave some insight into the source of the heterogeneity among the univariate ORs, therefore and suggest that our pooled estimates based on adjusted and subgroup analyses are not subject to the same caveat.

We have only examined the potential direct effect of alcohol use on HIV status. As discussed further in this report, alcohol use could be associated with HIV indirectly through other risk factors such as high-risk sexual behavior, gender violence, and presence of other STDs. Detailed analysis to investigate the effects of alcohol use on these potential intermediate variables could shed more light on this complex relationship between alcohol use and HIV infection.

Finally, the analysis suffers from the vagaries in the way alcohol use was measured across the studies. This had the immediate effect of forcing aggregation of alcohol use into a very crude yes/no dichotomy. In the long run, such categorization works against an in-depth understanding of the relationship between alcohol use and HIV infection. The knowledge base will be advanced significantly if standardized measures of alcohol use and abuse are adopted in future studies.

There are several potential mechanisms that may explain the observed association between alcohol consumption and increased risk of HIV. In most African countries, alcohol is consumed in small bars and other informal alcohol-serving establishments patronized by high-risk men seeking new sex partners.18,36 As a central nervous depressant, alcohol increases sexual risk taking by reducing inhibitions and diminishing perception of exposure risks.11 Thus, the social context prevailing in these places combined with alcohol use may contribute in increased transmission of HIV by facilitating high-risk encounters.

HIV risk factors and high-risk sexual behaviors have been shown to be related to drinking as well. Alcohol use has as an example been associated with higher rates of unprotected intercourse,21,37 failure to use condoms appropriately,21 and increased frequency of sexual activity and/or number of sexual partners.21,38,39 Other demonstrated associations include gender violence, sexual assault, and rape11,21,40,41 factors that are known to increase women’s vulnerability to HIV, and susceptibility to other STDs4 which is known to be associated with increased risk of HIV.42 Furthermore, there is a growing body of evidence that implicates chronic alcohol ingestion with compromised immune response43,44 and increased susceptibility to HIV infection.45–47

Overall this review of the published literature confirms that alcohol is an important risk factor for HIV infection in Africa. The accumulated evidence suggests additionally that prevention efforts should focus on groups most likely to experience alcohol problems, such as frequent, heavy, and symptomatic drinkers, and needs to take into account the social context in places where alcohol is consumed. In this regard, modification and implementation of extant simple and efficacious methods that are graduated to increasing involvement with alcohol, e.g., Brief Interventions developed by the WHO,48 could be viable alternatives.

Levels of alcohol consumption in many African countries are increasing, mainly because of the changing drinking patterns from low alcohol content traditional home-brews to recreational use of high alcohol content commercial brews49–51 and increased availability and accessibility of alcoholic beverages.51 This trend and the strength of the association between drinking and HIV status observed in this study suggest that alcohol use may amplify the current and future course of the epidemic. Thus, effective interventions directed toward this modifiable behavior may have substantial impact in reducing the devastating impact of the epidemic in this region of the world.

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