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Prevalence of Risk Factors for Hepatitis C Virus in HIV-Infected and HIV/Hepatitis C Virus-Coinfected Patients

Bollepalli, Srigayatri MD*; Mathieson, Kathleen PhD*; Bay, Curt PhD*; Hillier, Amy PAC*; Post, John MD*; Van Thiel, David H. MD†; Nadir, Abdul MD*

Sexually Transmitted Diseases: June 2007 - Volume 34 - Issue 6 - pp 367-370
doi: 10.1097/01.olq.0000240295.35457.b1

Methods: A sample of patients with HIV completed a questionnaire identifying their demographic characteristics and risk factors for hepatitis C virus (HCV). A chart review was conducted to confirm the information obtained using the questionnaire. Risk factors associated with coinfection status at α level of 0.1 in univariate analysis were entered into a multivariate Cox regression model.

Results: Of the 242 HIV-positive patients analyzed, 168 were HIV-infected and 74 were HIV/HCV-coinfected. Risk factors that were significantly different between HIV-monoinfected and HIV/HCV-coinfected subjects included intravenous drug use, snorting drugs, sharing razors or toothbrushes, being in prison, the presence of one or more tattoos, sex for money or drugs, sex with an intravenous drug user and man who has sex with men. In a multivariate regression model, only intravenous drug use remained as a significant risk factor/predictor of HCV/HIV coinfection. A subanalysis identified risk factors more prevalent among coinfected men who have sex with men, including intravenous drug use, sharing razors/toothbrushes, tattoos, sex for money or drugs, sex with an intravenous drug user, and a history of having 11 or more sexual partners. A history of having had a sexually transmitted disease and 11 or more sex partners was more prevalent among HIV-monoinfected men who have sex with men.

Conclusions: HIV/HCV coinfection was associated with intravenous drug use but not with sexual risk factors.

This study was conducted to examine the prevalence of sexual and nonsexual risk factors for hepatitis C virus infection between HIV-monoinfected and HIV/hepatitis C virus-coinfected patients.

From *Maricopa Medical Center (MMC) Phoenix, Arizona; and †St. Luke's Hospital, Milwaukee, Wisconsin

Correspondence: Abdul Nadir, MD, 2601 E. Roosevelt Street, Phoenix, AZ 85008. E-mail:

Received for publication March 26, 2006, and accepted July 25, 2006.

© Copyright 2007 American Sexually Transmitted Diseases Association