Sexually Transmitted Diseases:
Cost-Effectiveness of Surveillance Strategies After Treatment for High-Grade Anal Dysplasia in High-Risk Patients
Assoumou, Sabrina A. MD*; Mayer, Kenneth H. MD†‡; Panther, Lori A. MD, MPH†‡; Linas, Benjamin P. MD, MPH*§; Kim, Jane J. PhD¶
Form the *Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, MA; †Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; ‡The Fenway Institute, Boston, MA; §Boston University School of Public Health, Boston Medical Center, Boston University School of Medicine, Boston, MA; and ¶Department of Health Policy and Management, Harvard School of Public Health, Boston, MA
The authors thank Erika D’agata, MD, MPH, who provided guidance and critical review of the manuscript.
Supported by the Harvard Medical School Center for Excellence in Minority Health and Health Disparities (Health Disparities Post Graduate Fellowship funded by Health Resources and Services Administration, Bureau of Health Professions grant). S.A.A. was supported by the Harvard Medical School Center for Excellence in Minority Health and Health Disparities (Health Disparities Post Graduate Fellowship funded by Health Resources and Services Administration, Bureau of Health Professions grant), J.J.K. is supported, inpart, by the National Cancer Institute (1R01CA160744-01A1). B.P.L. is supported, in part, by the National Institute of Drug Abuse (R01 DA031059).
Conflicts of interest: L.A.P. has received honoraria from Merck as a member of the speakers’ bureau. K.H.M. received research support from Merck, Bristol-Myers Squibb, and Gilead. For the remaining authors, no conflicts of interest were declared.
Role of funding sources: Agencies funding this study have no role in thecollection, analysis, or interpretation of data.
Correspondence: Sabrina A. Assoumou, MD, Boston Medical Center, Boston University School of Medicine, One Boston Medical Center Place, 850 Harrison Ave, Dowling Ground, Boston, MA 02118. E-mail: email@example.com.
Received for publication May 30, 2012, and accepted November 21, 2012.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (http://www.stdjournal.com).
Background: Anal cancer is one of the most common cancers affecting human immunodeficiency virus (HIV)–infected male patients. Currently, there is no consensus on posttreatment surveillance of HIV-infected men who have sex with men (MSM) who have been treated for high-grade intraepithelial neoplasia (HGAIN), the likely precursor to anal cancer.
Objective: The aim of this study was to assess the cost-effectiveness of a range of strategies for anal cancer surveillance in HIV-infected MSM previously treated for HGAIN.
Methods: We developed a Markov model to project quality-adjusted life expectancy, lifetime costs, and the incremental cost-effectiveness ratios of 5 strategies using high-resolution anoscopy (HRA) and/or anal cytology testing after treatment.
Results: Performing HRA alone at 6- and 12-month visits was associated with a cost-effectiveness ratio of $4446 per quality-adjusted life year gained. In comparison, combined HRA and anal cytology at both visits provided greater health benefit at a cost of $17,373 per quality-adjusted life year gained. Our results were robust over a number of scenarios and assumptions including patients’ level of immunosuppression. Results were most sensitive to test characteristics and cost, as well as progression rates of normal to HGAIN and HGAIN to cancer.
Conclusions: Our results suggest that combined HRA and anal cytology at 6 and 12 months may be a cost-effective surveillance strategy after treatment of HGAIN in HIV-infected MSM.
The incidence of anal cancer has increased during the era of highly active antiretroviral therapy (HAART), whereas in contrast, other human immunodeficiency virus (HIV)–related malignancies have become less common.1–3 HIV-infected men who have sex with men (MSM) are at higher risk for developing anal cancer than all other populations. The incidence of anal cancer in this particular group is more than 80 times higher than that in HIV-uninfected individuals.4–7 Nearly half of HIV-infected individuals living in the United States are MSM, and establishing cost-effective protocols for the prevention of anal cancer should be an important component in the care of HIV-infected patients who are living longer during the HAART era.8
Screening HIV-infected MSM with annual anal cytology has been shown to be cost-effective, with an incremental cost-effectiveness ratio (ICER) compared with no screening of $16,600 per quality-adjusted life year (QALY) saved, which is similar to other accepted screening tests such as colon cancer screening.9 High-resolution anoscopy (HRA) is a technique used to detect high-grade anal intraepithelial neoplasia (HGAIN)10,11 which is the likely precursor to anal cancer. Once identified by HRA, high-grade lesions can be treated with office-based ablation or intraoperative ablation. Algorithms for follow-up evaluation after treatment of HGAIN have been proposed,12 but there is currently no consensus on how to best manage this high-risk population posttreatment. Assessing the value of alternative management strategies would inform practice guidelines.
Our objective was to evaluate the cost-effectiveness of alternative follow-up strategies after treatment of HGAIN in HIV-infected MSM. We developed a decision-analytic model to synthesize the epidemiologic, clinical, and economic data on recurrent anal disease and estimated the clinical benefits, costs, and cost-effectiveness of alternative management strategies.
MATERIALS AND METHODS
We developed a state-transition Markov model using TreeAge Pro 2009 (TreeAge, Williamstown, MA) to estimate the health and economic outcomes of surveillance strategies for MSM after treatment of HGAIN. HIV-infected MSM start in the Markov model health states defined by HPV-associated anal disease and HIV status (Fig. 1), including normal (no disease), low-grade anal intraepithelial neoplasia (LGAIN), HGAIN, anal cancer and death. We simulated a cohort of 30-year-old HIV-infected MSM after treatment for HGAIN, which includes anal intraepithelial neoplasia (AIN) 2 or 3. Initial surveillance and monitoring for AIN occurred in 6-month cycles. Participants progressed through the different health states based on follow-up results after treatment for HGAIN. The model simultaneously simulated the natural history of HPV and HIV diseases and used transition probabilities from the literature to move participants through health states over time.9,10,13 We assumed that disease regression from HGAIN was only possible after treatment. For the base case, we assumed that patients had a CD4 count greater than 500 cells/mm3, but we used sensitivity analyses to account for improved CD4 count after HAART initiation at a CD4 count less than 500 cells/mm3.
We evaluated 5 surveillance strategies in HIV-infected MSM who had previously been treated for AIN 2 or 3: (1) HRA at 6 months followed by anal cytology at 12 months, (2) HRA at 6 months followed by HRA at 12 months, (3) combined HRA and anal cytology at 6 months followed by anal cytology at 12 months, (4) combined HRA and anal cytology at 6 months followed by HRA at 12 months, and (5) combined HRA and anal cytology at 6 months followed by combined HRA and anal cytology at 12 months. All abnormal anal cytology test results were confirmed with HRA evaluation. Supplemental Digital Content Figure 1, http://links.lww.com/OLQ/A54 depicts the follow-up algorithm for patients with HGAIN.
Health outcomes, expressed as QALYs, and costs associated with alternative surveillance strategies were projected for a cohort of 30-year-old HIV-infected MSM over the lifetime. Strategies were compared using the ICER, which is defined as the additional cost of a specific strategy divided by the additional clinical benefit, compared with the next less costly strategy. Strategies that were less effective and more costly than an alternate strategy (i.e., strongly dominated) and strategies with a higher ICER than a more effective alternative strategy (i.e., weakly dominated) were eliminated from the calculations. Although there is no stringent cost-effectiveness threshold below which an intervention would be considered good value for money, a common benchmark in the United States includes $100,000/QALY gained. The analysis was conducted from the societal perspective, including costs irrespective of payor. As recommended for economic evaluations in the United States, future costs and health benefits were discounted at an annual rate of 3%.14 Costs were expressed in 2011 US dollars. We performed a series of deterministic sensitivity analyses to identify parameters with the greatest impact on cost-effectiveness. Based on the results, we included important parameters in a probabilistic sensitivity analysis in which we defined key parameter values as distributions and used second-order Monte Carlo simulation to perform 1000 cohort simulations.
Table 1 summarizes model input values assumed in the base case analysis.9–11,13,16–22,36,37 Data obtained from the literature included information on background mortality rate; natural history of HPV and HIV diseases; operating characteristics of screening and diagnostic tests; effectiveness of treatment for HGAIN; mortality rate from anal cancer; costs associated with screening, diagnosis, and treatment of HGAIN and anal cancer; and HIV treatment cost.
The following assumptions were made for the base case: (1) all positive anal cytology test results were subsequently evaluated by HRA; (2) screening coverage with anal cytology was assumed to be 100%; (3) all detected HGAIN and anal cancer cases were treated; (4) all lesions were treated with outpatient ablation and did not require intraoperative surgical intervention; (5) HAART was initiated at CD4 cell count less than 500 cells/mm3; and (6) recurrent HGAIN was assumed to have a natural history similar to anal dysplasia before treatment.
Natural History of Anal Dysplasia
Information on the rate of disease recurrence as well as disease progression and regression was obtained from the literature.9,10,13 Because the natural history of anal disease in patients who had been treated was not available, we used available data on untreated patients.10,13 Transition probabilities accounted for the impact of HPV disease. Transition from HGAIN to anal cancer has not been well documented in clinical studies; therefore, we used an estimate from a published study that used cancer incidence data to calibrate this parameter.9 Five-year survival from anal cancer of 61.8% reported by the Surveillance, Epidemiology and End Results program of the National Cancer Institute15 was used to reflect excess mortality due to disease.
Estimates of diagnostic tests operating characteristics were obtained from the literature.9,16,17 Data from the largest prospective study on HIV-infected MSM were used to estimate the sensitivity (81%) and specificity (63%) of anal cytology testing.16,17 High-resolution anoscopy test characteristics were derived from a longitudinal study of anal squamous intraepithelial lesions, with 95% sensitivity and 91% specificity.9,11,17
Health-Related Quality of Life
Health outcomes were expressed in QALYs to capture mortality and morbidity associated with a particular health state. We used previously reported health utility weights for HGAIN.18,19 We used published health state preferences for gastrointestinal cancer (0.58) as a proxy for anal cancer quality weights. HIV-related quality of life was a function of CD4 count and was informed by the literature.20 Joint health state preferences for HPV- and HIV-related disease were estimated using standard multiplicative assumptions. A utility multiplier of 0.98 was applied to patients with HGAIN.18
Costs included direct medical costs that incorporated cost of screening and diagnostic tests, as well as cost for HGAIN treatment. Cost estimates were obtained from the 2011 Medicare fee schedule.21 Cost of monthly HIV care included inpatient care and outpatient care and was informed by the literature.22 In sensitivity analyses, we included the cost of HAART initiation because we assumed that antiretroviral therapy was initiated at CD4 count below 500. All costs were updated to 2011 US dollars using the medical care component of the Consumer Price Index.23
For 30-year-old HIV-infected MSM with prior HGAIN treatment, surveillance with HRA at 6 months and anal cytology at 12 months (HRA 6/anal cytology 12) led to a life expectancy of 40.03 years and a discounted quality-adjusted life expectancy (QALE) of 21.48 QALYs at a lifetime discounted cost of $61,536 (Table 2). Compared with HRA 6/anal cytology 12, HRA at 6 and 12 months (HRA 6/HRA 12) was associated with an incremental life expectancy gain of 0.1716 and a discounted QALE gain of 0.0723 QALY at an incremental cost of $322, corresponding to an ICER of $4446/QALY gained. Combined HRA and cytology at 6 months, coupled with either HRA or cytology at 12 months, was associated with higher lifetime costs but lower life expectancies than HRA at 6 and 12 months and were therefore dominated. Compared with HRA6/HRA12, combined anal cytology and HRA at 6 and 12 months was associated with an incremental life expectancy gain of 0.2762 year, a QALE gain of 0.1061, and a discounted lifetime cost of $63,701, corresponding to an ICER of $17,373/QALY gained.
Deterministic Sensitivity Analysis
The cost-effectiveness of posttreatment surveillance was most sensitive to estimates of test characteristics, cost, and disease progression rate. Although a strategy combining HRA and anal cytology at both visits was affected by disease progression rate from normal to HGAIN and from HGAIN to cancer, the ICER remained stably below a threshold of $100,000/QALY (Table 3).
Impact of Disease Progression Rate and Cost
When the estimate of the rate of disease progression from normal to HGAIN was decreased over a plausible range, the ICER of combined anal cytology and HRA at 6 and 12 months increased from $17,373/QALY gained to $46,133/QALY gained. When the rate of disease progression from normal to HGAIN was increased over a plausible range, the ICER decreased from $17,373/QALY gained to $6298/QALY gained. The sensitivity of diagnostic tests also had an impact on the cost-effectiveness of surveillance strategies. When decreasing the sensitivity of HRA to 85%, the combined strategy of HRA with cytology became more attractive compared with a strategy of HRA alone, yielding a shift from $17,373 to $8160/QALY gained. Furthermore, variations in HGAIN treatment effectiveness also impacted the cost-effectiveness ratio, which, nonetheless, remained below the $100,000/QALY threshold. Increasing the discount rate from 3% to 10% shifted the cost-effectiveness ratio from $17,373 to $33,460/QALY gained because the gains in health benefit are generally downstream from the costs. Costs of treating HGAIN and anal cancer had a little impact on the cost-effectiveness of results.
Probabilistic Sensitivity Analysis
We performed 1000 simulations in which the input values for disease progression, test characteristics, cost of diagnostic tests, treatment efficacy and cost, and quality weights were varied simultaneously. We found that combined HRA and anal cytology at 6- and 12-month visits was the optimal strategy in 91% of simulations, HRA 6/HRA 12 was optimal in 8%, and other strategies were optimal in less than 1% of simulations (Supplemental Digital Content Fig. 2, http://links.lww.com/OLQ/A55).
Impact of CD4 Count Response to HAART
We performed a sensitivity analysis to account for an increase in CD4 count after HAART initiation. The following 2 CD4 count strata were considered: stratum A included CD4 count less than 200 cells/mm3, and stratum B represented CD4 count between 200 and 500 cells/mm3. We used the approach that follows for our analysis. Information on disease progression was obtained from the literature.10,13 Transition probabilities accounted for the combined impact of HPV and HIV disease, with more rapid disease progression at lower CD4 counts. We used information from a large observational cohort study to estimate CD4 count response to HAART initiation.24 Those in stratum A (CD4 count <200 cells/mm3) reached 500 cells/mm3 in approximately 5 years, whereas those in stratum B (200 and 500 cells/mm3) required approximately 1.5 years. We observed that irrespective of variations in CD4 count, combined HRA and cytology performed at 6 and 12 months remained the most cost-effective strategy. Incremental cost-effectiveness ratios were $15,354/QALY and $13,556/QALY gained for strata A and B, respectively. Ratios remained below the threshold of $100,000/QALY (Supplemental Digital Content Tables 1 and 2, http://links.lww.com/OLQ/A56 and Supplemental Digital Content 1, http://links.lww.com/OLQ/A57).
There is no consensus on the best subsequent management of HIV-infected MSM who have been treated for HGAIN. The results of this analysis suggest that repeated HRA is an effective and cost-effective surveillance modality. Surveillance strategies that included HRA at the 6- and 12-month visits, with or without anal cytology testing, were more effective than using HRA only for confirmatory testing of abnormal anal cytology testing. Our analysis revealed that both strategies (HRA 6/HRA 12 and combined HRA and cytology at both visits) were cost-effective; however, the combined strategy extended life expectancy and QALE while remaining below the commonly cited threshold of $100,000/QALY gained. HIV providers and guideline panels can use these results in the deliberations to improve outcomes after HIV-infected MSM are diagnosed and treated for HPV-associated disease.
The cost-effectiveness ratio remained robustly below a commonly cited threshold of $100,000 per QALY over a wide range of sensitivity analyses. Our results were most influenced by test characteristics and cost, as well as progression rate of normal to HGAIN and HGAIN to cancer, suggesting that further studies of HPV expression in MSM in the HAART era are warranted, given trends toward earlier initiation of treatment and longer survival. In addition, probabilistic sensitivity analysis incorporating uncertainty in parameters included in the model revealed that combined HRA and anal cytology at 6- and 12-month visits was the optimal strategy in 91% of simulations.
Previous studies have shown that annual screening of HIV-infected MSM is cost-effective9; however, there are no published studies on the cost-effectiveness of alternative surveillance strategies after treatment for HGAIN. In the early HAART era, Goldie et al.9 showed that annual screening with anal cytology was cost-effective, with a ratio of $16,600 per QALY saved. A more recent analysis by Lam et al.25 concluded that direct use of HRA was the most cost-effective strategy to screen for HGAIN in HIV-infected MSM. These 2 analyses were performed from a US perspective; in contrast, Karnon et al.18 found that screening high-risk MSM for anal cancer in the United Kingdom was not cost-effective. This discrepancy was likely observed given the lower rates of anal cancer in the United Kingdom compared with that in the United States. The reasons for differences in incidence warrant further exploration. Our results were in line with other HIV-related interventions such as genotypic resistance testing before antiretroviral therapy initiation or prophylaxis for Pneumocystis jiroveci pneumonia. Incremental cost-effectiveness ratios adjusted for inflation were $35,067 per QALY gained and $29,043 per QALY gained, respectively.20,26
There are several limitations to our study. The natural history of anal dysplasia with or without treatment has not been well defined. Furthermore, the efficacy of secondary prevention for anal cancer has yet to be proven in a large randomized controlled trial.27 Although uncertainty remains about the ability of secondary screening to prevent future anal cancers, clinical reality dictates that providers select an immediate course of action when caring for patients with a history of anal dysplasia. Our analysis uses decision analytic methods to provide a rational approach to making decisions about management despite imperfect information. We used the best available data about disease progression and treatment efficacy and performed multiple sensitivity analyses to explore the impact of uncertainty on our results. Although future data could shed new light on the conclusions of this analysis, no such data are immediately forthcoming, and decisions must be made today on the best surveillance strategy for patients with a history of anal dysplasia. Our results provide clinicians and guideline panels with information on which to formulate decisions. Our analyses showed that our findings are stable over a wide range of assumptions including variations in the rates of progression from normal to HGAIN or HGAIN to cancer. Our estimates could be further refined if better estimates of the long-term outcomes of treating HGAIN in an outpatient setting were available. Furthermore, our findings may not be generalizable to a population with severe disease that could not be managed in an outpatient setting or to other high-risk groups with anal cancer such as women with a history of high-grade cervical lesions. Furthermore, utility values used to generate QALYs were based on gastrointestinal cancers and were not specific to anal cancer. These inputs might impact the clinical benefits observed in our analysis.
In conclusion, our analysis suggests that combined HRA and anal cytology at 6- and 12-month visits may be a cost-effective follow-up strategy for HIV-infected MSM who have been treated for HGAIN. Our hope is that these findings contribute to the informed discussions on how to improve outcomes for HIV-infected MSM who are living longer during the HAART era. Future studies are needed on the acceptability of HGAIN treatment among patients and health care providers.
1. Chiao EY, Krown SE, Stier EA, et al.. A population-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the HIV epidemic. J Acquir Immune Defic Syndr 2005; 40: 451–455.
2. Long JL, Engels EA, Moore RD, et al.. Incidence and outcomes of malignancy in the HAART era in an urban cohort of HIV-infected individuals. AIDS 2008; 22: 489–496.
3. Piketty C, Selinger-Leneman H, Grabar S, et al.. Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapy. AIDS 2008; 22: 1203–1211.
4. Ries LAG, Young JL, Keel GE, et al.. SEER Survival Monograph: Cancer Survival Among Adults: U.S. SEER Program, 1988–2001. Patient and Tumor Characteristics. Chapter 5. Magaret M. Madeleine and Laura M. Newcomer. Bethesda, MD: National Cancer Institute, SEER Program, NIH Pub. No. 07-6215, 2007.
5. Ries LAG, Harkins D, Krapcho M, et al. SEER Cancer Statistics Review, 1975–2003, National Cancer Institute. Bethesda, MD. Available at: http://seer.cancer.gov/csr/1975_2003/
, based on November 2005 SEER data submission, posted to the SEER Web site, 2006. Accessed February 11, 2010.
6. Daling JR, Weiss NS, Hislop TG, et al.. Sexual practices, sexually transmitted diseases, and the incidence of anal cancer. N Engl J Med 1987; 317: 973–977.
7. Silverberg MJ, Lau B, Justice AC, et al.. The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin Infect Dis 2012; 54: 1026–1034.
8. CDC. HIV prevalence estimates—US, 2006. MMWR Morb Mortal Wkly Rep 2008; 57: 1073–1076.
9. Goldie SJ, Kuntz KM, Weinstein MC, et al.. The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA 1999; 281: 1822–1829.
10. Palefsky JM, Holly EA, Ralston ML, et al.. High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS 1998; 12: 495–503.
11. Jay N, Berry JM, Hogeboom CJ, et al.. Colposcopic appearance of anal squamous intraepithelial lesions: Relationship to histopathology. Dis Colon Rectum 1997; 40: 919–928.
12. Chin-Hong PV, Palefsky JM. Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis 2002; 35: 1127–1134.
13. Palefsky JM, Holly EA, Hogeboom CJ, et al.. Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17: 314–319.
14. Gold MR, Siegel JE, Russell LB, et al. (eds). Cost-Effectiveness in Health and Medicine. New York: Oxford University Press; 1996.
16. Chiao EY, Giordano TP, Palefsky JM, et al.. Screening HIV-infected individuals for anal cancer precursor lesions: A systematic review. Clin Infect Dis 2006; 43: 223–233. Epub 2006 Jun 7.
17. Palefsky JM, Holly EA, Ralston ML, et al.. Anal cytological abnormalities and anal HPV infection in men with Centers for Disease Control group IV HIV disease. Genitourin Med 1997; 73: 174–180.
18. Karnon J, Jones R, Czoski-Murray C, et al.. Cost-utility analysis of screening high-risk groups for anal cancer. J Public Health (Oxf) 2008; 30: 293–304. Epub 2008 Jun 17. Erratum in: J Public Health (Oxf) 2009;31:194.
19. Kim JJ, Goldie SJ. Health and economic implications of HPV vaccination in the United States. N Engl J Med 2008; 359: 821–832.
20. Freedberg KA, Scharfstein JA, Seage GR 3rd, et al.. The cost-effectiveness of preventing AIDS-related opportunistic infections. JAMA 1998; 279: 130–136. Erratum in: JAMA 1999 Jun 2;281(21): 1989.
22. Schackman BR, Gebo KA, Walensky RP, et al.. The lifetime cost of current human immunodeficiency virus care in the United States. Med Care 2006; 44: 990–997.
23. Consumer Price Index-Medical Care Component. U.S. Department of Labor, Bureau of Labor and Statistics. Available at: www.bls.gov/cpi/cpid09av.pdf
. Accessed October 5, 2012.
24. Gras L, Kesselring AM, Griffin JT, et al.. ATHENA, Netherlands National Observational Cohort Study.CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater. J Acquir Immune Defic Syndr 2007; 45: 183–192.
25. Lam JM, Hoch JS, Tinmouth J, et al.. Cost-effectiveness of screening for anal precancers in HIV-positive men. AIDS 2011; 25: 635–642.
27. Sax PE, Islam R, Walensky RP, et al.. Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysis. Clin Infect Dis 2005; 41: 1316–1323.
28. Palefsky JM. Antiretroviral therapy and anal cancer: The good, the bad, and the unknown. Sex Transm Dis 2012; 39: 501–503.
29. Arias L. United States Life Tables, 2006. National Vital Statistics Reports, Vol. 58, No. 21, June 28, 2010.
30. Melnikow J, Kulasingam S, Slee C, et al.. Surveillance after treatment for cervical intraepithelial neoplasia: Outcomes, costs, and cost-effectiveness. Obstet Gynecol 2010; 116: 1158–1170.
31. Surawicz CM, Critchlow C, Sayer J, et al.. High grade anal dysplasia in visually normal mucosa in homosexual men: Seven cases. Am J Gastroenterol 1995; 90: 1776–1778.
32. Nathan M, Hickey N, Mayuranathan L, et al.. Treatment of anal human papillomavirus–associated disease: A long term outcome study. Int J STD AIDS 2008; 19: 445–449.
33. Goldstone SE, Kawalek AZ, Huyett JW. Infrared coagulator: A useful tool for treating anal squamous intraepithelial lesions. Dis Colon Rectum 2005; 48: 1042–1054.
34. Cranston RD, Hirschowitz SL, Cortina G, et al.. A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int J STD AIDS 2008; 19: 118–120.
35. Goldstone RN, Goldstone AB, Russ J, et al.. Long-term follow-up of infrared coagulator ablation of anal high-grade dysplasia in men who have sex with men. Dis Colon Rectum 2011; 54: 1284–1292.
36. Marks DK, Goldstone SE. Electrocautery ablation of high-grade anal squamous intraepithelial lesions in HIV-negative and HIV-positive men who have sex with men. J Acquir Immune Defic Syndr 2011; 59: 259–265.
26. Hu D, Goldie SJ. The economic burden of noncervical human papillomavirus disease in the United States. Am J Obstet Gynecol 2008; 198: e1–e7.
This article has been cited 1 time(s).
Human Papillomavirus, Anal Cancer, and Screening Considerations among HIV-Infected Individuals
AIDS Reviews, 15(2):
Supplemental Digital Content
© Copyright 2013 American Sexually Transmitted Diseases Association