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Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0b013e3181fc6c65
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Estimating the Direct Costs of Pelvic Inflammatory Disease in Adolescents: A Within-System Analysis

Trent, Maria MD, MPH*; Ellen, Jonathan M. MD*; Frick, Kevin D. PhD†

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From the *Division of General Pediatrics and Adolescent Medicine, Johns Hopkins School of Medicine, Baltimore, MD; and †Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

Correspondence: Maria Trent, MD, MPH, Division of General Pediatrics and Adolescent Medicine, Johns Hopkins School of Medicine, 200 N. Wolfe Street, #2064 Baltimore, MD 21287.

Received for publication June 6, 2010, and accepted September 8, 2010.

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Abstract

We used 2008–2009 physician and hospital charges to estimate the direct cost of medical care per case of pelvic inflammatory disease. The estimated average total charge per episode was $3,025 (SD: $4155). The estimated average charge for patients treated in ambulatory (outpatient clinic and emergency department) settings was $7440 lower than for those treated on inpatient units.

Pelvic inflammatory disease (PID) is a common reproductive health problem affecting approximately 1 million women each year in the United States,1 with significant longitudinal morbidity observed among affected women.2–4 Economic analyses using adult data have suggested that outpatient treatment is the most cost-effective strategy for PID management5; however, few studies have incorporated adolescent-specific cost parameters. In order to develop a strategic approach to adolescent care, additional cost estimates are needed for care settings utilized by adolescent girls. The goal of this study was to estimate the direct costs of PID care and factors that may contribute to higher costs among adolescents and young adults cared for in a large urban university-based hospital system.

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METHODS

Medical records for patients aged 12 to 21 years, who were treated for PID as a primary diagnosis in a large academic hospital center between May 1, 2008 and April 30, 2009, were identified using International Classification of Diseases, Ninth Revision (ICD-9) coding and extraction from 2 administrative datasets. The first dataset identified patients based on hospital charges generated for the visits. The patients identified in this larger database included codes for pelvic inflammation (614.3) and salpingitis (614.9) as well as non-PID sexually transmitted infection(STI) (098.0) codes to ensure that all complicated STIs were captured. A single reviewer evaluated medical records to verify PID diagnoses. Within the institution, separate billing coders are employed to evaluate medical records for billing. Using a priori inclusion criteria, records that (1) did not have PID or salpingitis as the final diagnosis were removed from the dataset even if it was clear that the patient was charged for PID based on billing data and (2) non-PID STI charges that were misclassified were also excluded to ensure that the best estimates for pediatric PID care could be ascertained. The patients remaining in the dataset were then cross-matched with the physician charges dataset so that the total charges for each visit could be estimated. Even though some patients were cared for in multiple settings (outpatient clinic, emergency department [ED], and/or the inpatient unit), all patients who were ultimately admitted to the hospital were considered inpatients. Within this system, charges for ambulatory visits resulting in a hospital stay are not separated from the inpatient charges. The final dataset included demographic data (race, insurance status, location of care, clinical service, admission status), and the total physician and hospital-related charges for the visit. Data were evaluated using linear regression analyses. Age was evaluated as a potential confounder in regression analyses using the change in estimate approach, given the potential modifications in the care plan based on adolescent age.

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RESULTS

After excluding all of the non-PID STI visits (N = 26) and the visits (N = 20) with verified alternate diagnoses (e.g., endometriosis with pelvic pain, c-section with pelvic adhesions noted during delivery), 152 PID patients and 172 visits remained in the dataset. The mean age was 17.8 years (standard deviation [SD]: 2.1 years). The majority was black (91.3), low income based on Medicaid or uninsured status (93.6%), cared for in an ED setting (69.9%), and had 1 PID diagnosis visit during study period (98.6%). Only 8.1% sought care in an outpatient department inclusive of adolescent medicine, general pediatrics, internal medicine, and the gynecological service teams. The mean overall charge for PID within the institution was $3025 (SD: $4155), mean hospital charges were $2775 (SD: $3998), and mean physician billing costs were $327 (SD: $454). As seen in Table 1 below, the charges for inpatient care were significantly higher than outpatient care for all charge types.

Table 1
Table 1
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Of the 37 inpatients, 6 (16%) were hospitalized on adolescent psychiatry units. The average total charge for care for adolescents with PID who were also being cared for on the psychiatry unit was $13,368 (SD: $4939) compared with $8483 (SD: $5131) on medical units. The average length of stay (LOS) on a medical unit was 2.4 days (SD: 1.6) and on the psychiatry unit was 8 days (SD: 3.5) (P < 0.001). Care on the inpatient psych unit was on average $4885 higher than on medical units (β = $4885; SE β: 2277, P = 0.04). Excluding adolescents treated for PID on inpatient psychiatric units (N = 6) given additional the costs of psychiatric care and longer LOS for this small subset of girls, adolescents cared for in ambulatory units (ED/clinic) generated PID charges that were $7440 lower (β = −$7440, SE β: $473; 95% CI: −$8356, −$6525) than medical inpatient unit, controlling for age. Patients who were treated in an outpatient clinic had charges that were $703 lower (β = −703; 95% CI: −298, 1109) than those treated in the ED setting, controlling for age.

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DISCUSSION

This analysis using hospital charges demonstrates that the estimated direct costs for initial PID treatment are considerably lower in ambulatory settings. These estimates are higher than anticipated based on inflation adjusted comparisons of published data6–9 and highly variable within a single hospital system. For example, the anticipated total direct costs for outpatient management of PID in 2009 would range between $300 and $600, using data from multiple sources that includes claims and hospital billing and the standard deviation for outpatient charges in this study were $763. For hospitalized patients, the LOS has been reduced from almost 5 to 2 days,8 but the mean inpatient charge was above the upper limit of the range ($5817–$8117) observed for inpatient treatment not involving surgery in 2009 dollars.6–9 Adjusting for inflation over the last 2 decades allows for comparison of total cost; however, care must be taken when interpreting the findings because this adjustment does not account for the change in inpatient services over time.

The Centers for Disease Control and Prevention currently does not recommend hospitalization for all adolescent patients,10 therefore the variability observed between units likely derives from differences in the severity of illness and/or ability to tolerate an outpatient disposition at the time of initial evaluation. Although only the final disposition is reflected here, all patients were seen initially in an ambulatory setting for the initial evaluation. Although psychiatric patients also diagnosed with PID appear to have the highest charges of any disposition group, most of these charges clearly derive from psychiatric service-related billing charges. This group, however, represents 16% of the adolescents hospitalized for PID treatment and the findings indicate the vulnerable status of sexually active adolescents with serious mental health disorders.

The findings from this study must be considered in light of several general limitations. This study is a cross-sectional retrospective study utilizing administrative billing data and ICD-9 coding within a single hospital center located in urban America. The severity of presentation and rates of hospitalization may be reflective of the prevalence of STIs and/or hospital policies around management of adolescents with PID. This study also utilized charges instead of claims data that provide information on reimbursed amounts or a cost accounting system. Use of charges may provide an overestimate of actual direct costs because it includes a markup and is subject to prenegotiated rates for insurance reimbursement. Since these charges are variable based on each insurer, charges allow for more accurate comparisons of costs between units within the same institution. Charges may also be a more reasonable estimate of direct costs due to state regulations that affect hospital billing practices in Maryland. While there is the potential for misclassification, the electronic medical system was reviewed to verify diagnostic data to support a PID diagnosis and charts that were misclassified using the charge-capture system were removed from the data base. This work, however, is limited to the assessment of direct medical costs associated with an initial PID diagnostic visit. Most patients did not return for a clinical follow-up within the academic center for the 72-hour follow-up advised by the Centers for Disease Control and Prevention.10 While it is possible that care was sought outside of the system, prior research suggests that less than 25% of adolescent patients return for the recommended follow-up visit.11 Despite the fact that failure to return for care results in cost-savings in terms of calculating overall PID expenditures; pediatric patients need the follow-up visits for risk reduction and family planning counseling based on studies that have included risk assessments for adolescent girls with PID.11 Indirect costs (e.g., travel, wait time, loss of wages) are also not reflected in the estimated costs of PID care.

One major finding in this study is that the majority of adolescents within this academic setting were seen for care in EDs rather than in outpatient clinics inclusive of the general pediatric, adolescent medicine, and gynecology clinics at a higher estimated direct cost for ambulatory care. Utilization of EDs likely reflects the absence of available primary care among uninsured patients, referral for additional evaluation by a local healthcare provider outside of the institution, and/or the hours that adolescents need to seek services for acute reproductive care. Although recent research has demonstrated promising strategies to improve PID care in ED settings,12,13 prior research indicates that adolescents often receive suboptimal care in emergency medical departments.14–16 Efforts to increase utilization of outpatient clinics by adolescents for PID care and to standardize care across units may reduce the within-system costs for PID treatment, while also improving quality of care.17

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REFERENCES

1. Centers for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. STD facts: Pelvic inflammatory disease. Available at: http://www.cdc.gov/std/PID/STDFact-PID.htm#common. Accessed 21 June, 2009.

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3. Westrom L. Effect of acute pelvic inflammatory disease on fertility. Am J Obstet Gynecol 1975; 121:707–713.

4. Ness RB, Trautmann G, Richter HE, et al. Effectiveness of treatment strategies of some women with pelvic inflammatory disease: A randomized trial. Obstet Gynecol 2005; 106:573–580.

5. Smith KJ, Ness RB, Roberts MS. Hospitalization for pelvic inflammatory disease: A cost-effectiveness analysis. Sex Transm Dis 2007; 34:108–112.

6. Magid D, Douglas JM Jr. Doxycycline compared with azithromycin for treating women with genital Chlamydia trachomatis. Ann Intern Med 1996; 124:389.

7. Yeh JM, Hook EW III, Goldie SJ. A refined estimate of the average lifetime cost of pelvic inflammatory disease. Sex Transm Dis 2003; 30:369–378.

8. Washington AE, Katz P. Cost of and payment source for pelvic inflammatory disease: Trends and projections, 1983 through 2000. JAMA 1991; 266:2565–2569.

9. Rein DB, Kassler WJ, Irwin KL, et al. Direct medical cost of pelvic inflammatory disease and its sequelae: Decreasing, but still substantial. Obstet Gynecol 2000; 95:397–402.

10. Centers for Disease Control and Prevention, Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 2006; 55:1–94.

11. Trent M, Chung SE, Burke M, et al. Results of a randomized controlled trial of a brief behavioral intervention for pelvic inflammatory disease in adolescents. J Pediatr Adolesc Gynecol 2010; 23:96–101.

12. Balamuth F, Zhao H, Mollen C. Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: Results of a brief, educational intervention. Pediatr Emerg Care 2010; 26:85–92.

13. Trent M, Judy SL, Ellen JM, et al. Use of an institutional intervention to improve quality of care for adolescents treated in pediatric ambulatory settings for pelvic inflammatory disease. J Adolesc Health 2006; 39:50–56.

14. Beckmann KR, Melzer-Lange MD, Gorelick MH. Emergency department management of sexually transmitted infections in US adolescents: Results from the national hospital ambulatory medical care survey. Ann Emerg Med 2004; 43:333–338.

15. Trent M, Ellen JM, Walker A. Pelvic inflammatory disease in adolescents: Care delivery in pediatric ambulatory settings. Pediatr Emerg Care 2005; 21:431–436.

16. Benaim J, Pulaski M, Coupey SM. Adolescent girls and pelvic inflammatory disease: Experience and practices of emergency department pediatricians. Arch Pediatr Adolesc Med 1998; 152:449–454.

17. Trent M, Millstein SG, Ellen JM. Gender-based differences in fertility beliefs and knowledge among adolescents from high sexually transmitted disease-prevalence communities. J Adolesc Health 2006; 38:282–287.

Cited By:

This article has been cited 1 time(s).

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