Abstract: We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.
Case report examines a Neisseria gonorrhoeae isolate with a nonmosaic penA allele that exhibited decreased susceptibility to ceftriaxone and other extended-spectrum cephalosporins.
From the *CDC Division of STD Prevention, Atlanta, GA; †Oklahoma State Department of Health, HIV/STD Service, Oklahoma City, OK; and ‡Texas Department of State Health Services, Laboratory Services Section, Austin, TX
Conflict of Interest and Sources of Funding: None declared.
Disclaimer: The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Correspondence: A. Jeanine Abrams, PhD, Centers for Disease Control and Prevention, Division of STD Prevention, Laboratory Reference and Research Branch 1600 Clifton Rd. NE MS A12 Atlanta, GA 30333. E-mail: email@example.com.
Received for publication February 21, 2017, and accepted April 4, 2017.