Abstract: Syphilis has been known to present in a myriad of symptoms throughout the ages, and until this day, the diagnosis remains elusive to the modern physician. We present 2 unusual cases of syphilis that posed diagnostic challenges even in the current era of new and advancing diagnostic tests.
We report 2 cases of syphilis in patients with human immunodeficiency virus infection that presented as tumor-like lesions. 16S ribosomal RNA sequencing was performed to facilitate the diagnosis.
From the *Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, and †Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore
Conflict of interest: None declared.
Correspondence: Ray Junhao Lin, MBBS, MRCP(UK), MMed (Int Med), 11 Jalan Tan Tock Seng, Singapore 308433, Republic of Singapore. E-mail: firstname.lastname@example.org.
Received for publication September 22, 2016, and accepted December 16, 2016.