Syphilitic Hepatitis Treated With Doxycycline in an HIV-Infected Patient and Review of the Literature

Bork, Jacqueline T. MD*†; Macharia, Thomas MD*†; Choi, Julia MD; Gilliam, Bruce L. MD*†; Buchwald, Ulrike K. MD*†

Sexually Transmitted Diseases:
doi: 10.1097/OLQ.0000000000000143
Case Report
Abstract

Abstract: An HIV-infected male patient who had sex with men and with a penicillin allergy presented with liver dysfunction due to secondary syphilis and was successfully treated with doxycycline. This case highlights that syphilitic hepatitis may be overlooked in this particular population, and health care providers should be attuned to this diagnosis. Doxycycline may be an acceptable alternative to penicillin for treatment of this clinical syndrome.

In Brief

This is a case describing syphilitic hepatitis in an HIV-infected patient with a penicillin allergy, treated with doxycycline, and a review of the current literature.

Author Information

From the *Department of Medicine, Division of Infectious Diseases, University of Maryland Medical Center, Baltimore, MD; †Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD; and ‡Department of Pathology, University of Maryland Medical Center, Baltimore, MD

Acknowledgments: Informed consent for photography was obtained and appropriately documented.

Conflict of interest: None declared.

Correspondence: Jacqueline T. Bork, MD, Department of Medicine, Division of Infectious Diseases, University of Maryland Medical Center, 725 W. Lombard St, 5th Floor, Baltimore, MD 21201. E-mail jbork@umm.edu.

Received for publication March 5, 2014, and accepted April 10, 2014.

© Copyright 2014 American Sexually Transmitted Diseases Association